84547-85-3

Basic information

• Product Name: 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid
• Synonyms: 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid;4-CHLORO-1-METHYL-PYRAZOLE-3-CARBOXYLIC ACID;4-chloro-1-methyl-1H-pyrazole-3-carboxylic acid(SALTDATA: FREE);1H-Pyrazole-3-carboxylic acid, 4-chloro-1-methyl-;4-chloro-1-methyl-3-pyrazolecarboxylic acid
• CAS NO: 84547-85-3
• Molecular Formula: C₅H₅ClN₂O₂
• Molecular Weight: 160.56
• Mol File: 84547-85-3.mol
• Article Data: 4

Chemical Properties

• Melting Point: 219-221 °C(Solv: acetic acid (64-19-7))
• Boiling Point: 327°C at 760 mmHg
• Flash Point: 151.6°C
• Appearance: /
• Density: 1.56g/cm³
• Vapor Pressure: 8.41E-05mmHg at 25°C
• Refractive Index: 1.62
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.78±0.25(Predicted)
• CAS DataBase Reference: 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid(84547-85-3)
• EPA Substance Registry System: 4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid(84547-85-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 84547-85-3(Hazardous Substances Data)

Usage

Uses

4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid is a reagent used in the preparation of a library of acylaminoacrylates for fragment-based identification of selective small molecule covalent inhibitors of the cysteine protease papain.

InChI:InChI=1/C5H5ClN2O2/c1-8-2-3(6)4(7-8)5(9)10/h2H,1H3,(H,9,10)

Upstream product

• 15878-44-1 1,3-Dimethyl-4-chlor-pyrazol 
• 25016-20-0 1-methylpyrazole-3-carboxylic acid 
• 694-48-4 1,3-dimethyl-1H-pyrazole 
• 942853-19-2 ethyl 4-chloro-1-methyl-pyrazole-3-carboxylate 

Downstream Products

• 1005785-54-5 4-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-fluorophenyl]-1-methyl-1H-pyrazole-3-carboxamide 
• 1005785-52-3 4-chloro-N-[5-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}oxy)-2-methylphenyl]-1-methyl-1H-pyrazole-3-carboxamide 
• 1259931-94-6 C₃₈H₄₀ClF₂N₇O₂ 
• 1310347-64-8 4-chloro-1-methyl-1H-pyrazole-3-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide 

Relevant articles and documents

IRAK DEGRADERS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same. The compounds include an IRAK binding moiety capable of binding to IRAK4 and a degradation inducing moiety (DIM). The DIM could be DTM a ligase binding moiety (LBM) or lysine mimetic. The compounds could be useful as IRAK protein kinase inhibitors and applied to IRAK mediated disorders.

PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR

The present invention relates to processes for preparing pyrazole derivatives of Formula (I) and salts and pharmaceutical compositions of the salts thereof, useful as modulators of 5-HT2A serotonin receptor activity. The present invention also relates to intermediates used in the processes, and their preparation. The present invention also relates to salts of compounds of Formula (I) and pharmaceutical compositions thereof