845609-54-3Relevant articles and documents
Discovery of benzoylpiperazines as a novel class of potent and selective GlyT1 inhibitors
Pinard, Emmanuel,Alberati, Daniela,Borroni, Edilio,Fischer, Holger,Hainzl, Dominik,Jolidon, Synese,Moreau, Jean-Luc,Narquizian, Robert,Nettekoven, Matthias,Norcross, Roger D.,Stalder, Henri,Thomas, Andrew W.
scheme or table, p. 5134 - 5139 (2009/05/26)
Screening of the Roche compound library led to the identification of the benzoylpiperazine 7 as a structurally novel GlyT1 inhibitor. The SAR which was developed in this series resulted in the discovery of highly potent compounds displaying excellent sele
BENZOYL-PIPERAZINE DERIVATIVES
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Page/Page column 17-18, (2008/06/13)
The invention relates to compounds of formula wherein the substituents are described herein. The compounds may be used in the treatment of illnesses based on the glycine uptake inhibitor, such as psychoses, pain, neurodegenerative disfunction in memory and learning, schizophrenia, dementia and other diseases in which cognitive processes are impaired, such as attention deficit disorders or Alzheimer's disease.