845871-66-1

Basic information

• Product Name: Thieno[3,2-c]pyridin-4-amine, 3-(4-aminophenyl)-7-(3-furanyl)-
• CAS NO: 845871-66-1
• Molecular Formula: C17H13N3OS
• Molecular Weight: 307.376
• Mol File: 845871-66-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thieno[3,2-c]pyridin-4-amine, 3-(4-aminophenyl)-7-(3-furanyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Thieno[3,2-c]pyridin-4-amine, 3-(4-aminophenyl)-7-(3-furanyl)-(845871-66-1)
• EPA Substance Registry System: Thieno[3,2-c]pyridin-4-amine, 3-(4-aminophenyl)-7-(3-furanyl)-(845871-66-1)

Safety Data

• Hazardous Substances Data: 845871-66-1(Hazardous Substances Data)

Upstream product

• 330793-01-6 (4-tert-butoxycarbonylaminophenyl)boronic acid pinacol ester 
• 832695-08-6 tert-butyl 4-(4-amino-7-iodothieno[3,2-c]pyridin-3-yl)phenylcarbamate 
• 832695-09-7 3-(4-aminophenyl)-7-iodothieno[3,2-c]pyridin-4-amine 
• 248924-59-6 3-furylboronic acid pinacol ester 

Downstream Products

• 845870-87-3 C₂₅H₂₀N₄O₂S 

Relevant articles and documents

Thienopyridine ureas as dual inhibitors of the VEGF and Aurora kinase families

In an effort to identify multi-targeted kinase inhibitors with a novel spectrum of kinase activity, a screen of Abbott proprietary KDR inhibitors against a broad panel of kinases was conducted and revealed a series of thienopyridine ureas with promising activity against the Aurora kinases. Modification of the diphenyl urea and C7 moiety of these compounds provided potent inhibitors with good pharmacokinetic profiles that were efficacious in mouse tumor models after oral dosing. Compound 2 (ABT-348) of this series is currently undergoing Phase I clinical trials in solid and hematological cancer populations.