84596-08-7Relevant articles and documents
Imidazo[1,2- a]pyridine derivatives as aldehyde dehydrogenase inhibitors: Novel chemotypes to target glioblastoma stem cells
Quattrini, Luca,Gelardi, Edoardo Luigi Maria,Coviello, Vito,Sartini, Stefania,Ferraris, Davide Maria,Mori, Mattia,Nakano, Ichiro,Garavaglia, Silvia,La Motta, Concettina
, p. 4603 - 4616 (2020/06/08)
Glioblastoma multiforme (GBM) is the deadliest form of brain tumor. It is known for its ability to escape the therapeutic options available to date thanks to the presence of a subset of cells endowed with stem-like properties and ability to resist to cyto
NOVEL PROCESSES FOR THE MANUFACTURE OF PROPANE-1-SULFONIC ACID {3-[5-(4-CHLORO-PHENYL)-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL]-2,4-DIFLUORO-PHENYL}-AMIDE
-
Page/Page column 23, (2012/02/05)
According to the present invention there are provided novel processes for the manufacture of the compound of formula (1) as well as novel synthesis routes for key intermediates used in those processes.
Novel compounds as metabotropic glutamate receptor antagonists
-
Page/Page column 20, (2008/06/13)
The present invention relates to compounds of formula (I) wherein A, E G, J, L, M, R1, R2, and R3 are as defined in the specification and claims. The invention also relates to pharmaceutical compositions containing such compounds and methods for preparing the compounds and compositions. The compounds are metabotropic glutamate receptor antagonists and are useful for the treatment of a variety of CNS disorders.