846-63-9

Basic information

• Product Name: 2-(1-naphthyl)-5-phenyloxazole
• Synonyms: Oxazole, 2-(1-naphthalenyl)-5-phenyl-; 2-(1-Naphthyl)-5-phenyloxazole; 2-alpha-Naphthyl-5-phenyloxazole; NSC 24857; Oxazole, 2-(1-naphthyl)-5-phenyl-; alpha-NPO; 2-(naphthalen-1-yl)-5-phenyl-1,3-oxazole; 5-(naphthalen-1-yl)-2-phenyl-1,3-oxazole
• CAS NO: 846-63-9
• Molecular Formula: C₁₉H₁₃NO
• Molecular Weight: 271.3126
• EINECS: 212-689-7
• Product Categories: Scintillators
• Mol File: 846-63-9.mol
• Article Data: 8

Chemical Properties

• Melting Point: 104-106 °C
• Boiling Point: 451°C at 760 mmHg
• Flash Point: 192.6°C
• Density: 1.178g/cm³
• Vapor Pressure: 6.71E-08mmHg at 25°C
• Refractive Index: 1.647
• Storage Temp.: ?20°C
• Solubility: Sparingly Soluble (4.1E-4 g/L) (25°C). Soluble most organic solvents.
• PKA: 0.39±0.10(Predicted)
• BRN: 210666
• CAS DataBase Reference: 2-(1-naphthyl)-5-phenyloxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-naphthyl)-5-phenyloxazole(846-63-9)
• EPA Substance Registry System: 2-(1-naphthyl)-5-phenyloxazole(846-63-9)

Safety Data

• Hazard Codes: F,C
• Statements: 20/21/22-34-11
• Safety Statements: 22-24/25-45-36/37/39-26-16
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 846-63-9(Hazardous Substances Data)

Usage

Description

2-(1-naphthyl)-5-phenyloxazole, also known as αNPO, is an organic fluor compound with unique photophysical properties. It exhibits strong fluorescence and high quantum yield, making it a versatile molecule for various applications.

Uses

Used in Laser Dyes:
2-(1-naphthyl)-5-phenyloxazole is used as a laser dye due to its strong fluorescence and high quantum yield. It can be synthesized using Stille coupling followed by purification, resulting in the vNPO and allylNPO monomers.
Used in Scintillation Counters:
In the field of radiation detection, 2-(1-naphthyl)-5-phenyloxazole serves as a scintillation counter or wavelength shifter in solution scintillators. Its photophysical properties allow for efficient conversion of radiation energy into visible light, enhancing the detection capabilities of scintillation systems.
Used in Wavelength Shifters:
2-(1-naphthyl)-5-phenyloxazole is also utilized as a wavelength shifter in solution scintillators. It can effectively shift the emitted radiation wavelengths to a range that is more suitable for detection by photomultiplier tubes or other light-sensitive devices, improving the overall performance of scintillation systems.

Upstream product

• 94300-99-9 N-(2-oxo-2-phenylethyl)-1-naphthamide 
• 99747-74-7 1-naphthyl triflate 
• 879-18-5 naphthalene-1-carbonic acid chloride 
• 1006-68-4 5-phenyloxazole 
• 90-11-9 1-Bromonaphthalene 
• 118-31-0 (naphth-1-yl)methylamine 
• 122-78-1 phenylacetaldehyde 
• 13504-46-6 1-naphtylaldehyde oxime 
• 536-74-3 phenylacetylene 
• 21857-14-7 5-Phenyl-2-oxazoline 
• 1351445-39-0 N,N,N-trimethyl-1-naphthalenaminium trifluoromethanesulfonate 
• 86-56-6 N,N-dimethyl-1-naphthalenamine 
• 884866-01-7 1-(4-methylbenzensulfonyl)-4-phenyl-1H-1,2,3-triazole 
• 66-77-3 1-naphthaldehyde 

Downstream Products

• 120970-37-8 3-methyl-2-[1]naphthyl-5-phenyl-oxazolium; toluene-4-sulfonate 
• 97458-59-8 C₃₅H₂₄N₂O₂ 

Relevant articles and documents

Synthesis method of oxazole heterocyclic compound

The invention belongs to the technical field of organic synthesis and medicines, and particularly relates to a synthesis method of an oxazole heterocyclic compound. Aryl aldehyde and a triazole derivative are used as raw materials and are heated to react in the presence of trichloromethane and rhodium acetate catalysts to obtain the oxazole heterocyclic compound. By using the method provided by the invention, under the condition of heating and stirring, the oxazole heterocyclic derivative can be obtained at a relatively high yield after reaction for 3-12 hours. According to the method disclosed by the invention, the oxazole heterocyclic derivative is simply, conveniently and efficiently synthesized by using simple and easily available raw materials through a one-step method, and a simple and efficient new synthesis method with wide substrate universality is provided for synthesizing the oxazole heterocyclic derivative.

Palladium-Catalyzed C-H Arylation of (Benzo)oxazoles or (Benzo)thiazoles with Aryltrimethylammonium Triflates

The C-H arylation of (benzo)oxazoles or (benzo)thiazoles with aryltrimethylammonium triflates was carried out via Pd-catalyzed C-H/C-N cleavage. Oxazoles, thiazoles, benzoxazole, and benzothiazole were arylated using activated and deactivated aryltrimethylammonium triflates to give 2-aryl(benzo)oxazoles or 2-aryl(benzo)thiazoles in reasonable to excellent yields.

Synthesis of oxazoles through copper-mediated aerobic oxidative dehydrogenative annulation and oxygenation of aldehydes and amines

A fragment-assembling strategy is used to form oxazoles from aryl acetaldehydes, amines, and molecular oxygen under mild conditions (see scheme). The transformation is highly efficient with the removal of six hydrogen atoms, including the cleavage of four C(sp3)-H bonds. Copyright