846023-26-5

Basic information

• Product Name: Benzene, 1-ethoxy-2-iodo-4-nitro-
• CAS NO: 846023-26-5
• Molecular Formula: C8H8INO3
• Molecular Weight: 293.061
• Mol File: 846023-26-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Benzene, 1-ethoxy-2-iodo-4-nitro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-ethoxy-2-iodo-4-nitro-(846023-26-5)
• EPA Substance Registry System: Benzene, 1-ethoxy-2-iodo-4-nitro-(846023-26-5)

Safety Data

• Hazardous Substances Data: 846023-26-5(Hazardous Substances Data)

Upstream product

• 89487-91-2 2-iodo-4-nitrophenol 
• 75-03-6 ethyl iodide 
• 110-86-1 pyridine 
• 7553-56-2 iodine 
• 7697-37-2 nitric acid 
• 103-73-1 Phenetole 
• 57533-24-1 bis-(4-ethoxy-phenyl)-diiodo-λ⁴-tellane 
• 699-08-1 1-ethoxy-4-iodobenzene 
• 614-73-3 1-ethoxy-2-iodobenzene 

Downstream Products

• 885483-00-1 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-(4-hydroxybut-1-ynyl)-3-quinolinecarbonitrile 
• 846023-41-4 2-cyano-N-(2,4-dichloro-5-methoxyphenyl)-3-[(4-ethoxy-3-iodophenyl)amino]acrylamide 
• 846023-52-7 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-ethoxy-7-iodo-3-quinolinecarbonitrile 
• 846023-27-6 4-ethoxy-3-iodo-aniline 

Relevant articles and documents

Inhibition of Src kinase activity by 7-ethynyl-4-phenylamino-3-quinolinecarbonitriles: Identification of SKS-927

Of a series of 7-ethynyl-3-quinolinecarbonitriles, the most potent Src inhibitory activity was observed with 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[4-(4-methylpiperazi n-1-yl)but-1-ynyl]-3-quinolinecarbonitrile (SKS-927). Variation of the so

Process for preparation of 4-amino-3-quinolinecarbonitriles

This invention discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile comprising combining an amine compound with a cyanoacetic acid and an acid catalyst to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline in an alcoholic solvent and a trialkylorthoformate to yield a 3-amino-2-cyanoacrylamide; combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride in acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 4-amino-3-quinolinecarbonitrile and also discloses a process for the preparation of a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile comprising combining a disubstituted 3-amino thiophene with a cyanoacetamide and trialkylorthoformate in an alcoholic solvent to obtain a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride and acetonitrile, butyronitrile, toluene or xylene, optionally in the presence of a catalyst to yield a 7-amino-thieno[3,2-b]pyridine-6-carbonitrile and also discloses a process for the preparation of a 4-amino-3-quinolinecarbonitrile by combining an amine compound with a cyanoacetic acid and a peptide coupling reagent to obtain a suspension; filtering the suspension to yield a cyanoacetamide; condensing the cyanoacetamide with an optionally up to tetra-substituted aniline, an alcoholic solvent, and triethylorthoformate to yield a 3-amino-2-cyanoacrylamide; and combining the 3-amino-2-cyanoacrylamide with phosphorus oxychloride to yield a 4-amino-3-quinolinecarbonitrile.