84620-27-9

Basic information

• Product Name: 2-phenyl-4-allyl-4-methyl-Δ²-oxazolin-5-one
• Synonyms: 2-phenyl-4-allyl-4-methyl-Δ²-oxazolin-5-one
• CAS NO: 84620-27-9
• Molecular Weight: 215.252
• Mol File: 84620-27-9.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-phenyl-4-allyl-4-methyl-Δ²-oxazolin-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-phenyl-4-allyl-4-methyl-Δ²-oxazolin-5-one(84620-27-9)
• EPA Substance Registry System: 2-phenyl-4-allyl-4-methyl-Δ²-oxazolin-5-one(84620-27-9)

Safety Data

• Hazardous Substances Data: 84620-27-9(Hazardous Substances Data)

Upstream product

• 2198-64-3 N-benzoyl-L-alanine 
• 13302-43-7 (S)-2-phenyl-4-methyl-5(4H)-oxazolone 
• 106-95-6 allyl bromide 
• 886466-65-5 5-allyloxycarbonyloxy-4-methyl-2-phenyloxazole 
• 98-88-4 benzoyl chloride 
• 53777-87-0 N-benzoyl-alanine allyl ester 
• 5162-44-7 1-bromo-4-butene 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 114234-15-0 N-<1-(N,N-Dimethylcarbamoyl)-1-methylbut-3-enyl>benzamid 
• 2198-64-3 N-Benzoylalanine 
• 84537-31-5 2-phenyl-4-methyl-4-(3-methyl-2-butenyl)-Δ²-oxazolin-5-one 
• 65-85-0 benzoic acid 
• 107267-46-9 2-Allyl-3-(dimethylamino)-2-methyl-2H-azirin 

Downstream Products

• 160281-26-5 N-Benzoyl-(S)-α-(2-propenyl)-α-alanine 
• 96886-55-4 (S)-α-allylalanine 
• 84537-32-6 2-phenyl-2-(1,1-dimethyl-2-propenyl)-4-methyl-Δ³-oxazolin-5-one 
• 84537-31-5 2-phenyl-4-methyl-4-(3-methyl-2-butenyl)-Δ²-oxazolin-5-one 
• 56434-99-2 2-methyl-6-phenyl-pyridine; picrate 
• 51127-13-0 2-phenyl-4-methyl-4H-oxazolin-5-one 
• 46181-30-0 6-methyl-2-phenylpyridine 

Relevant articles and documents

Palladium-catalyzed asymmetric decarboxylative allylation of azlactone enol carbonates: Fast access to enantioenriched α-allyl quaternary amino acids

We report a fast protocol for the synthesis of enantioenriched quaternary 4-allyl oxazol-5-ones. The key step is a Pd-catalyzed enantioselective Tsuji allylation of azlactone allyl enol carbonates, which can be easily prepared starting from racemic α-amino acids. The use of (R,R)-DACH-phenyl Trost chiral ligand allowed the attainment of the allylated derivatives in very good yields (83–98 %) and with ee up to 85 %. Scaling up the allylation protocol to gram quantities did not affect the yields end ee values. The produced 4-allyl azlactones can be converted into the corresponding quaternary amino acids or submitted to further synthetic elaborations exploiting the allyl moiety as a handle for the attachment of alkyl and aryl groups. After hydrolysis of the azlactone ring, the zwitterionic amino acids can be attained in enantiopure or nearly optically pure form through only one recrystallization step.

Enantioselective quaternization of 4-substituted oxazol-5-(4H)-ones using recoverable Cinchona-derived dimeric ammonium salts as phase-transfer organocatalysts

Dimeric anthracenyldimethyl-derived Cinchona ammonium salts are used as chiral organocatalysts (5 mol %) for the enantioselective 4-alkylation of 4-substituted azlactones. The corresponding adducts bearing a new quaternary center were obtained with up to

Formation of Methyl 5,6-Dihydro-1,3(4H)-thiazine-4-carboxylates from 4-Allyl-1,3-thiazol-5(4H)-ones

The reaction of N-benzamid (1) with HCl or TsOH in MeCN or toluene yields a mixture of 4-allyl-4-methyl-2-phenyl-1,3-thiazol-5(4H)-one (5a) and allyl 4-methyl-2-phenyl-1,3-thiazol-2-yl sulfide (11; Scheme