84639-06-5Relevant articles and documents
A formal total synthesis of the telomerase inhibitor dictyodendrin B
Hirao, Shotaro,Yoshinaga, Yuki,Iwao, Masatomo,Ishibashi, Fumito
scheme or table, p. 533 - 536 (2010/09/20)
A formal synthesis of the telomerase inhibitory marine pyrrolocarbazole alkaloid dictyodendrin B is described. The key features are consecutive palladium-catalyzed cross-coupling reactions and intramolecular reductive coupling reaction to construct the pyrrolo[2,3-c]carbazole framework.
Cytokine inhibitors
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Page/Page column 53; 54, (2010/02/08)
Disclosed are compounds of formula (I) Where Ar1, X, Y, Q, W, R3, R4, R5, R6 and Ry are defined herein. The compounds of the invention inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. The compounds are also useful for treating diseases or conditions related to oncology and anticoagulant or fibrinolytic therapy. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.
β2-Agonists containing metabolically labile groups. II. The influence of ester groups in the aryl system
Albrecht,Heindl,Loge
, p. 57 - 60 (2007/10/02)
β2-Agonists which are derived from alkyl 7-hydroxy-indole-2-carboxylates are highly active bronchodilators. The corresponding carboxylic acids, which can be formed metabolically from the esters, have diminished activity. Thus these compounds ar
