847039-14-9

Basic information

• Product Name: Butanedioic acid, 2-hydroxy-3-[[4-(trifluoromethoxy)phenyl]methyl]-, dimethyl ester, (2S,3R)-
• CAS NO: 847039-14-9
• Molecular Formula: C14H15F3O6
• Molecular Weight: 336.265
• Mol File: 847039-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Butanedioic acid, 2-hydroxy-3-[[4-(trifluoromethoxy)phenyl]methyl]-, dimethyl ester, (2S,3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanedioic acid, 2-hydroxy-3-[[4-(trifluoromethoxy)phenyl]methyl]-, dimethyl ester, (2S,3R)-(847039-14-9)
• EPA Substance Registry System: Butanedioic acid, 2-hydroxy-3-[[4-(trifluoromethoxy)phenyl]methyl]-, dimethyl ester, (2S,3R)-(847039-14-9)

Safety Data

• Hazardous Substances Data: 847039-14-9(Hazardous Substances Data)

Upstream product

• 38115-87-6 malic acid dimethyl ester 
• 50824-05-0 4-trifluoromethoxybenzyl bromide 

Downstream Products

• 847039-17-2 2S-hydroxy-3R-(4-trifluoromethoxy-benzyl)-succinic acid 

Relevant articles and documents

DERIVATIVES OF HYDROXAMIC ACID AS METALLOPROTEINASE INHIBITORS

Compounds of formula (I) are inhibitors of matrix metalloproteinases, and are of use in the treatment of, for example fibrotic disease, multiple sclerosis, emphysemia, bronchitis and asthma: formula (I) wherein Ar represents an optionally substituted aryl, heteroaryl, C3-C8 cycloalkyl or heterocycloakyl group; R represents hydrogen or C1-C6 alkyl, or C3-C6 cycloalkyl; Alk represents a divalent C1-C5 alkylene or C2-C5 alkenylene radical; and R1 and R2 taken together with the nitrogen atom to which they are attached form a first heterocycloalkyl ring which is optionally fused to a second C3-C8 cycloalkyl or heterocycloalkyl ring, the said first and second rings being optionally substituted by at least one group of formula (II): formula (II) wherein m, p and n are independently 0 or 1; Z represents, hydrogen, or an optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms which is optionally fused to another optionally substituted carbocyclic or heterocyclic ring of from 5 to 7 ring atoms; Alk1 and Alk2 independently represent optionally substituted divalent C1-C3 alkylene radicals; X represents -0-, -S-, -S(O)-, -S(O2)-, -C(=O)-, -NH-, -NR3-, -S(O2)NH-, -S(O2)NR3-, -NHS(O2)-, or -NR3S(O2)-, where R3 is C1-C3 alkyl.