847199-91-1

Basic information

• Product Name: Carbamic acid, [(1R)-2-(1-ethyl-1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester
• CAS NO: 847199-91-1
• Molecular Formula: C18H26N2O2
• Molecular Weight: 302.417
• Mol File: 847199-91-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(1R)-2-(1-ethyl-1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1R)-2-(1-ethyl-1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(847199-91-1)
• EPA Substance Registry System: Carbamic acid, [(1R)-2-(1-ethyl-1H-indol-3-yl)-1-methylethyl]-, 1,1-dimethylethyl ester(847199-91-1)

Safety Data

• Hazardous Substances Data: 847199-91-1(Hazardous Substances Data)

Upstream product

• 7795-52-0 (-)-alpha-Methyltryptamine 

Downstream Products

• 847200-08-2 thiophene-2-sulfonic acid (3-{1-(tert-butyl-dimethyl-silanyloxy)-2-[2-(1-ethyl-1H-indol-3-yl)-1-methyl-ethylamino]-ethyl}-phenyl)-amide 

Relevant articles and documents

Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β3-adrenergic receptor agonists with high cell permeability

The synthesis and evaluation of a novel series of 1,7-cyclized indole-based human adrenergic receptor (β3-AR) agonists are reported. The synthesis of a variety of 1,7-cyclized indole part was accomplished by the Mitsunobu reaction or a ring closing metathesis (RCM) reaction. SAR studies revealed that expansion of the ring size resulted in considerable selectivity against the β1- and β2-ARs. Compound 26, an eight-membered ring analogue with a double bond on its 1,7-linker portion, was found to be a potent β3-AR agonist (EC50 = 0.75 nM, IA = 90%) with extremely high selectivity for the β3-AR over the β1- and β2-ARs.