84740-26-1

Basic information

• Product Name: (+)-6-β-D-Glucopyranosyl-5,7-dihydroxy-2H-1-benzopyran-2-one
• Synonyms: (+)-6-β-D-Glucopyranosyl-5,7-dihydroxy-2H-1-benzopyran-2-one;(+)-6-β-D-Glucopyranosyl-5,7-dihydroxycoumarin;(+)-Mulberroside B;Dauroside D;Mulberroside B
• CAS NO: 84740-26-1
• Molecular Formula: C15H16O9
• Molecular Weight: 340.28214
• Mol File: 84740-26-1.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (+)-6-β-D-Glucopyranosyl-5,7-dihydroxy-2H-1-benzopyran-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-6-β-D-Glucopyranosyl-5,7-dihydroxy-2H-1-benzopyran-2-one(84740-26-1)
• EPA Substance Registry System: (+)-6-β-D-Glucopyranosyl-5,7-dihydroxy-2H-1-benzopyran-2-one(84740-26-1)

Safety Data

• Hazardous Substances Data: 84740-26-1(Hazardous Substances Data)

Upstream product

• 133-89-1 UDP-glucose 
• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 
• 50-99-7 D-glucose 

Downstream Products

• 2732-18-5 5,7-dihydroxy-2H-chromen-2-one 

Relevant articles and documents

Biocatalytic C-Glucosylation of Coumarins Using an Engineered C-Glycosyltransferase

The enzymatic synthesis of coumarin C-glucosides by an engineered C-glycosyltransferase, MiCGTb-GAGM, was explored in vitro and in vivo. MiCGTb-GAGM exhibited a robust C-glucosylation capability toward structurally diverse coumarin derivatives. The whole-cell bioconversion of MiCGTb-GAGM was exploited for large-scale production of coumarin C-glucosides. Two C-glucosides exhibited potent SGLT2 inhibitory activities with IC50 values at 10-6 M. These findings provide cost-effective and practical synthetic strategies to generate structurally diverse and novel bioactive coumarin C-glycosides for drug discovery.