847448-34-4

Basic information

• Product Name: Glycine, N-[1-(3,4-dichlorophenyl)propyl]-, methyl ester
• CAS NO: 847448-34-4
• Molecular Formula: C12H15Cl2NO2
• Molecular Weight: 276.163
• Mol File: 847448-34-4.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Glycine, N-[1-(3,4-dichlorophenyl)propyl]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[1-(3,4-dichlorophenyl)propyl]-, methyl ester(847448-34-4)
• EPA Substance Registry System: Glycine, N-[1-(3,4-dichlorophenyl)propyl]-, methyl ester(847448-34-4)

Safety Data

• Hazardous Substances Data: 847448-34-4(Hazardous Substances Data)

Upstream product

• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 

Downstream Products

• 847448-00-4 {[1-(3,4-dichloro-phenyl)-propyl]-formyl-amino}-acetic acid methyl ester 
• 742108-32-3 1-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-1H-imidazole-4,5-dicarboxylic acid 5-methyl ester 
• 742107-86-4 1-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-1H-imidazole-4,5-dicarboxylic acid dimethyl ester 
• 742107-78-4 3-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-3H-imidazole-4-carboxylic acid 
• 112366-39-9 3-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-3H-imidazole-4-carboxylic acid methyl ester 
• 871343-28-1 3-[1-(3,4-dichloro-phenyl)-propyl]-2-mercapto-3H-imidazole-4-carbonyl chloride 

Relevant articles and documents

MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS

The present invention relates to a compound of formula (I), aN-oxide, a pharmaceutically acceptable addition salt, a quaternary amine and a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-6alkyl, C3-7

MERCAPTOIMIDAZOLES AS CCR2 RECEPTOR ANTAGONISTS

The present invention relates to a compound of formula (I), a N-oxide, a pharmaceutically acceptable addition salt, a quaternary amine or a stereochemically isomeric form thereof, wherein R1 represents hydrogen, C1-66alkyl, C3-7cycloalkyl, C1-66alkylo xyC1 -6alkyl, di(C1-6alkyl)aminoC1-6alkyl, aryl or heteroaryl; each R2 independently represents halo, C1-6alkyl, C1-6alkyloxy, C1-6alkylthio, polyhaloC1-6alkyl, polyhaloC1-6alkyloxy, cyano, aminocarbonyl, amino, mono-or di(C1-4alkyl)amino, nitro, aryl or aryloxy; R3 represents hydrogen, cyano, optionally subst ituted C1-66alkyl, C(=O)-O-R5, C(=O)-NR6aR6b, C(=S)-NR6aR6b, S(=O)2-NR6aR6b or C(=O)-R7; R4 represents hydrogen or C1-6alkyl; n is 1, 2, 3, 4 or 5; Z represents a cyclic ring system. The invention also relates to processes for preparing the compounds of formula (I), their use as CCR2 antagonists and pharmaceutical compositions comprising them.