847585-90-4Relevant articles and documents
PREVENTIVE AND / OR THERAPEUTIC AGENTS FOR SIP-MEDIATED DISEASES
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Paragraph 0196, (2021/04/22)
本發明之課題係提供一種將S1P5受體作動活性相對於S1P1受體作動活性之平衡經改善的化合物作為有效成份的醫藥組成物,以及將該醫藥組成物用於S1P5媒介疾病(例如,神經退化性疾病、多系統萎縮症、巴金森氏病)等之預防及/或治療的醫藥。 包含通式(V)(式中,各基的定義如說明書所載)所示之化合物或其藥學上可容許之鹽、及藥學上可容許之載體的醫藥組成物,係由於改善了S1P5受體作動活性相對於S1P1受體作動活性的平衡,故作為S1P5媒介疾病之預防及/或治療劑有用。 (式中,所有記號如說明書記載) An object
DIHYDRONAPHTHALENE DERIVATIVE
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Paragraph 0105, (2017/10/25)
A compound shown by general formula (I) (in the formula, all of the symbols are as defined in the specification) has selective S1P5 receptor agonist activity due to having a linker from a phenyl group to a cyclic substituent in a dihydronaphthalene skelet
AMINOCARBOXYLIC ACID DERIVATIVE AND MEDICINAL USE THEREOF
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, (2008/06/13)
The present invention relates to a compound represented by the formula (I), a salt thereof, an N-oxide form thereof, a solvate thereof, or a prodrug thereof, and a medicament containing the same. The compound represented by the formula (I) has an ability to bind to an S1P receptor (particularly, EDG-1, EDG-6, and/or EDG-8) and is useful for preventing and/or treating for rejection to transplantation, graft-versus-host disease, autoimmune diseases, allergic diseases, neurodegenerating diseases, and the like. wherein all symbols are described in the specification.