847613-62-1Relevant articles and documents
Chloramine-T mediated synthesis of 1,8-naphthyridinyl-1,3,4-oxadiazoles
Mogilaiah,Srinivas,Sudhakar, G. Rama
, p. 2014 - 2017 (2007/10/03)
3-Phenyl-1,8-naphthyridin-2(1H)-one 1 on reaction with ethyl chloroacetate affords ethyl (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetate 2, which on treatment with hydrazine hydrate yields (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1- yl)acetic acid hydrazide 3. The acid hydrazide 3 reacts with various aromatic aldehydes to give the corresponding (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl) acetic acid arylidenehydrazides 4. Oxidative cyclization of 4 with chloramine-T furnishes 1-(5-aryl-[1,3,4]-oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]naphthyridin- 2-ones 5. These compounds have been characterized on the basis of elemental analyses, IR, 1H NMR and MS. Compounds 5 have been screened for their antibacterial activity.