847613-63-2

Basic information

• Product Name: (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (4-methyl-benzylidene)-hydrazide
• Synonyms: (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (4-methyl-benzylidene)-hydrazide
• CAS NO: 847613-63-2
• Molecular Weight: 396.448
• Mol File: 847613-63-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (4-methyl-benzylidene)-hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (4-methyl-benzylidene)-hydrazide(847613-63-2)
• EPA Substance Registry System: (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetic acid (4-methyl-benzylidene)-hydrazide(847613-63-2)

Safety Data

• Hazardous Substances Data: 847613-63-2(Hazardous Substances Data)

Upstream product

• 104-87-0 4-methyl-benzaldehyde 
• 847613-61-0 (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetic acid hydrazide 
• 5174-92-5 3-phenyl-1,8-naphthyridin-2(1H)-one 
• 847613-60-9 ethyl (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)-acetate 

Relevant articles and documents

Chloramine-T mediated synthesis of 1,8-naphthyridinyl-1,3,4-oxadiazoles

3-Phenyl-1,8-naphthyridin-2(1H)-one 1 on reaction with ethyl chloroacetate affords ethyl (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl)acetate 2, which on treatment with hydrazine hydrate yields (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1- yl)acetic acid hydrazide 3. The acid hydrazide 3 reacts with various aromatic aldehydes to give the corresponding (2-oxo-3-phenyl-2H-[1,8]naphthyridin-1-yl) acetic acid arylidenehydrazides 4. Oxidative cyclization of 4 with chloramine-T furnishes 1-(5-aryl-[1,3,4]-oxadiazol-2-ylmethyl)-3-phenyl-1H-[1,8]naphthyridin- 2-ones 5. These compounds have been characterized on the basis of elemental analyses, IR, 1H NMR and MS. Compounds 5 have been screened for their antibacterial activity.