84774-99-2

Basic information

• Product Name: 5-(2-fluorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol
• Synonyms: imidazo[2,1-a]isoquinolin-5-ol, 5-(2-fluorophenyl)-2,3,5,6-tetrahydro-
• CAS NO: 84774-99-2
• Molecular Formula: C₁₇H₁₅FN₂O
• Molecular Weight: 282.3122
• Mol File: 84774-99-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 442.4°C at 760 mmHg
• Flash Point: 221.4°C
• Density: 1.32g/cm³
• Vapor Pressure: 1.32E-08mmHg at 25°C
• Refractive Index: 1.662
• CAS DataBase Reference: 5-(2-fluorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2-fluorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(84774-99-2)
• EPA Substance Registry System: 5-(2-fluorophenyl)-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ol(84774-99-2)

Safety Data

• Hazardous Substances Data: 84774-99-2(Hazardous Substances Data)

Upstream product

• 394-35-4 methyl 2-fluorobenzoate 
• 57327-93-2 2-(o-Tolyl)-2-imidazoline 
• 393-52-2 2-Fluorobenzoyl chloride 
• 445-29-4 o-fluoro-benzoic acid 

Relevant articles and documents

Antidepressant activity of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols

A series of 5-aryl-2,3,5,6-tetrahydroimidazo[2,1-a]isoquinolin-5-ols was prepared and evaluated for potential antidepressant activity in the reserpine-induced hypothermia model and selected central nervous system and autonomic activity tests. Several members of the series, notably the 4-chloro- and 4-fluorophenyl analogues, demonstrated pharmacological activity in the range of imipramine. Both compounds provided a marked potentiation of the 5-hydroxytryptophan-facilitated monosynaptic spike in the spinal cat preparation.