847802-91-9

Basic information

• Product Name: 6-hydroxy-N-Methyl-1-naphthaMide
• Synonyms: 6-hydroxy-N-Methyl-1-naphthaMide;6-hydroxy-N-Methylnaphthalene-1-carboxaMide;1-NaphthalenecarboxaMide, 6-hydroxy-N-Methyl-;6-hydroxy-N-methyl-1-Naphthalenecarboxamide
• CAS NO: 847802-91-9
• Molecular Formula: C₁₂H₁₁NO₂
• Molecular Weight: 201.22124
• Mol File: 847802-91-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 489.1±18.0 °C(Predicted)
• Appearance: /
• Density: 1.239±0.06 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: 2-8°C
• PKA: 9.15±0.40(Predicted)
• CAS DataBase Reference: 6-hydroxy-N-Methyl-1-naphthaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 6-hydroxy-N-Methyl-1-naphthaMide(847802-91-9)
• EPA Substance Registry System: 6-hydroxy-N-Methyl-1-naphthaMide(847802-91-9)

Safety Data

• Hazardous Substances Data: 847802-91-9(Hazardous Substances Data)

Usage

General Description

6-Hydroxy-N-methyl-1-naphthamide is a chemical compound with the molecular formula C12H11NO2. It is a derivative of 1-naphthylamine and contains a hydroxyl group and a methyl group. 6-Hydroxy-N-methyl-1-naphthamide is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is also used as a reagent in organic synthesis and as a building block for the production of various organic compounds. 6-Hydroxy-N-methyl-1-naphthamide has potential applications in the fields of medicine, agriculture, and chemical research due to its unique chemical properties and versatility.

Upstream product

• 2437-17-4 6-hydroxy-1-naphthoic acid 
• 74-89-5 methylamine 
• 593-51-1 methylamine hydrochloride 

Downstream Products

• 1058137-70-4 6-(7-(benzyloxy)-6-methoxyquinolin-4-yloxy)-N-methyl-1-naphthamide 
• 1058137-21-5 benzyl 1-((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)methyl)cyclo-propylcarbamate 
• 1058137-23-7 lucitanib 

Relevant articles and documents

PROCESS FOR PREPARING THE ANTI-TUMOR AGENT 6-(7-((1-AMINOCYCLOPROPYL) METHOXY)-6-METHOXYQUINOLIN-4-YLOXY)-N-METHYL-1-NAPHTHAMIDE AND ITS CRYSTALLINE

The present invention relates a new process to synthesize 6-(7-((l-aminocyclo-propyl)- methoxy)-6-methoxyquinolin-4-yloxy)-N-methyl- l -naphthamide (AL3810) by deprotection of substituted benzyl 1 -((6-methoxy-4-(5-(methylcarbamoyl)naphthalen-2-yloxy)quinolin-7-yloxy)- methyl)cyc-lopropylcarbamate (Formula I) under a diluted or weak acidic condition. A stable crystalline form of 6-(7-((l-aminocyclo-propyl)-methoxy)-6-methoxyquinolin-4-yloxy)-N- methyl- 1 -naphthamide has also been prepared.

NAPHTHALENE CARBOXAMIDES AND THEIR DERIVATIVES USEFUL AS NEW ANTI-ANGIOGENIC AGENTS

The invention relates to compounds represented by Formula (I) and to prodrugs thereof, pharmaceutically acceptable salts or solvates of said compounds or said prodrugs, wherein each of R1a-d , R2a-b , R3, and X1 are defined herein, The invention also relates to pharmaceutical compositions containing the compounds of Formula (I) and to methods of treating hyperproliferative disorders in a mammal by administering compounds of Formula(l).