847925-82-0

Basic information

• Product Name: C₁₆H₂₃N₅O₇
• Synonyms: C₁₆H₂₃N₅O₇
• CAS NO: 847925-82-0
• Molecular Weight: 397.388
• Mol File: 847925-82-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₆H₂₃N₅O₇(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₆H₂₃N₅O₇(847925-82-0)
• EPA Substance Registry System: C₁₆H₂₃N₅O₇(847925-82-0)

Safety Data

• Hazardous Substances Data: 847925-82-0(Hazardous Substances Data)

Upstream product

• 29475-64-7 N-methyl-D-alanine 

Relevant articles and documents

Cyclic depsipeptides, grassypeptolides D and e and Ibu- epidemethoxylyngbyastatin 3, from a Red Sea Leptolyngbya cyanobacterium

Two new grassypeptolides and a lyngbyastatin analogue, together with the known dolastatin 12, have been isolated from field collections and laboratory cultures of the marine cyanobacterium Leptolyngbya sp. collected from the SS Thistlegorm shipwreck in the Red Sea. The overall stereostructures of grassypeptolides D (1) and E (2) and Ibu-epidemethoxylyngbyastatin 3 (3) were determined by a combination of 1D and 2D NMR experiments, MS analysis, Marfey's methodology, and HPLC-MS. Compounds 1 and 2 contain 2-methyl-3-aminobutyric acid and 2-aminobutyric acid, while biosynthetically distinct 3 contains 3-amino-2-methylhexanoic acid and the β-keto amino acid 4-amino-2,2-dimethyl-3-oxopentanoic acid (Ibu). Grassypeptolides D (1) and E (2) showed significant cytotoxicity to HeLa (IC50 = 335 and 192 nM, respectively) and mouse neuro-2a blastoma cells (IC50 = 599 and 407 nM, respectively), in contrast to Ibu-epidemethoxylyngbyastatin 3 (neuro-2a cells, IC50 > 10 μM) and dolastatin 12 (neuro-2a cells, IC 50 > 1 μM).