848-63-5

Basic information

• Product Name: 3β,12β-Dihydroxy-5α-androstan-17-one
• Synonyms: 3β,12β-Dihydroxy-5α-androstan-17-one
• CAS NO: 848-63-5
• Molecular Formula: C19H30O3
• Molecular Weight: 306.4397
• Mol File: 848-63-5.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3β,12β-Dihydroxy-5α-androstan-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3β,12β-Dihydroxy-5α-androstan-17-one(848-63-5)
• EPA Substance Registry System: 3β,12β-Dihydroxy-5α-androstan-17-one(848-63-5)

Safety Data

• Hazardous Substances Data: 848-63-5(Hazardous Substances Data)

Upstream product

• 897047-26-6 5α-pregnane-3β,12β,17,20ξ-tetraol 
• 1202747-73-6 C₂₅H₃₆N₂O 
• 481-29-8 Epiandrosterone 

Relevant articles and documents

CHEMISTRY OF 3-BETA,12-DIHYDROXY-5-ALPHA-ANDROSTAN-17-ONES.

-

Scalable C-H Oxidation with Copper: Synthesis of Polyoxypregnanes

Steroids bearing C12 oxidations are widespread in nature, yet only one preparative chemical method addresses this challenge in a low-yielding and not fully understood fashion: Sch?necker's Cu-mediated oxidation. This work shines new light onto this powerf

-

Mass spectrometric degradation reactions of steroids with hydroxy groups in positions 12 and 17β depend on the configuration of the C-12 hydroxy group. In compounds with a 12α-hydroxy group, this group and the hydrogen in position 17α is eliminated as H2O. This reaction is followed by loss of a methyl radical. In the isomers with a 12β-hydroxy group this reaction is not possible. Here the loss of carbon 15-17 dominates the production of an ion by loss of two molecules of water. Key ions of mass 97 as well as M-44 and M-74 ions are produced by 17 keto steroids with a hydroxy group in position 12. If the rings A and B are cis-connected less specific degradation reactions are observed.