84807-90-9

Basic information

• Product Name: 12(S)-HETE-D8
• Synonyms: 12(S)-HETE-D8;12S-HYDROXY-5Z,8Z,10E,14Z-EICOSATETRAENOIC ACID-5,6,8,9,11,12,14,15-D8 ACID;ZNHVWPKMFKADKW-OPXGWVKSSA-N
• CAS NO: 84807-90-9
• Molecular Formula: C20H24D8O3
• Molecular Weight: 328.52
• Mol File: 84807-90-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 12(S)-HETE-D8(CAS DataBase Reference)
• NIST Chemistry Reference: 12(S)-HETE-D8(84807-90-9)
• EPA Substance Registry System: 12(S)-HETE-D8(84807-90-9)

Safety Data

• Hazardous Substances Data: 84807-90-9(Hazardous Substances Data)

Usage

Description

12(S)-HETE-D8, also known as deuterated 12(S)-HETE, is a stable isotope-labeled analog of 12(S)-hydroxy-5,8,10,14-eicosatetraenoic acid (12(S)-HETE), containing eight deuterium atoms at the 5, 6, 8, 9, 11, 12, 14, and 15 positions. It is a synthetic compound that serves as a valuable tool in the field of biochemistry and analytical chemistry.

Uses

Used in Biochemical Research:
12(S)-HETE-D8 is used as an internal standard for the quantification of 12(S)-HETE by gas chromatography (GC) or liquid chromatography-mass spectrometry (LC-MS). This application is crucial for accurate measurement and analysis of 12(S)-HETE levels in biological samples, which aids in understanding its role in various physiological and pathological processes.
Used in Cancer Research:
In the field of cancer research, 12(S)-HETE-D8 is used as a reference compound to study the role of 12(S)-HETE in tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. This knowledge is essential for developing targeted therapies and understanding the mechanisms of cancer progression and metastasis.
Used in Pharmaceutical Development:
12(S)-HETE-D8 can be employed in the development of drugs targeting the lipoxygenase pathway, as it helps in the identification and optimization of potential drug candidates. By using 12(S)-HETE-D8 as an internal standard, researchers can accurately assess the efficacy of these drug candidates in modulating 12(S)-HETE levels and their downstream effects.
Used in Quality Control and Validation:
In the pharmaceutical and biotechnology industries, 12(S)-HETE-D8 is used for quality control and validation of analytical methods and assays. It ensures the reliability and accuracy of the measurements, which is critical for the development and manufacturing of drugs and other biological products.