848175-28-0

Basic information

• Product Name: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide
• Synonyms: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide
• CAS NO: 848175-28-0
• Molecular Weight: 287.361
• Mol File: 848175-28-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(848175-28-0)
• EPA Substance Registry System: 2-([1,1'-biphenyl]-4-yl)-N-phenylacetamide(848175-28-0)

Safety Data

• Hazardous Substances Data: 848175-28-0(Hazardous Substances Data)

Upstream product

• 5728-52-9 (4-biphenylyl)acetic acid 
• 62-53-3 aniline 
• 39889-69-5 biphenyl-4-yl-acetyl chloride 

Relevant articles and documents

Studies and synthesis of substituted 4-biphenyl acetamide derivatives

A new series of substituted 4-biphenylamides have been synthesized by condensation of 4-biphenyl acetic acid with different primary amines (aromatic and aliphatic). 4-Biphenyl acetic acid was first treated with thionyl chloride in dry benzene to prepare substituted 4-biphenyl acetyl chloride, which is then treated with different aliphatic or aromatic amines to synthesize various substituted 4-biphenyl acid-amide derivatives. The structure of newly synthesized compounds has been established by analytical and spectral methods. These synthesized compounds have shown antifungal properties against Fusarium udum and Curvularia lunata.

The ketene-surrogate coupling: Catalytic conversion of aryl iodides into aryl ketenes through ynol ethers

tert-Butoxyacetylene is shown to undergo Sonogashira coupling with aryl iodides to yield aryl-substituted tert-butyl ynol ethers. These intermediates participate in a [1,5]-hydride shift, which results in the extrusion of isobutylene and the generation of aryl ketenes. The ketenes are trapped in situ with multiple nucleophiles or undergo electrocyclic ring closure to yield hydroxynaphthalenes and quinolines.