848188-30-7Relevant articles and documents
Design, synthesis, and evaluation of oxazole transthyretin amyloidogenesis inhibitors
Razavi, Hossein,Powers, Evan T.,Purkey, Hans E.,Adamski-Werner, Sara L.,Chiang, Kyle P.,Dendle, Maria T. A.,Kelly, Jeffery W.
, p. 1075 - 1078 (2007/10/03)
Ten oxazoles bearing a C(4) carboxyl group were synthesized and evaluated as transthyretin (TTR) amyloid fibril inhibitors. Substituting aryls at the C(2) position of the oxazole ring reveals that a 3,5-dichlorophenyl substituent significantly reduced amy