848192-90-5

Basic information

• Product Name: 1-benzhydryl-3-cyclopropyl-azetidin-3-ol
• Synonyms: 1-benzhydryl-3-cyclopropyl-azetidin-3-ol
• CAS NO: 848192-90-5
• Molecular Formula: C₁₉H₂₁NO
• Molecular Weight: 279.37614
• EINECS: -0
• Mol File: 848192-90-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-benzhydryl-3-cyclopropyl-azetidin-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzhydryl-3-cyclopropyl-azetidin-3-ol(848192-90-5)
• EPA Substance Registry System: 1-benzhydryl-3-cyclopropyl-azetidin-3-ol(848192-90-5)

Safety Data

• Hazardous Substances Data: 848192-90-5(Hazardous Substances Data)

Usage

Chemical Structure

1-benzhydryl-3-cyclopropyl-azetidin-3-ol

Type of Compound

Chemical compound used in pharmacology

Target Receptor

Selective antagonist for the cholecystokinin 1 receptor (CCK1)

Receptor Function

Involved in the regulation of appetite and energy balance

Potential Applications

Treatment of obesity and other metabolic disorders

Mechanism of Action

Blocks the effects of cholecystokinin, a hormone that promotes satiety and reduces food intake

Current Status

Under research for its therapeutic potential in managing conditions related to appetite and weight regulation

Upstream product

• 40320-60-3 N-benzhydryl 3-azetidinone 
• 23719-80-4 cyclopropylmagnesium bromide 
• 4333-56-6 cyclopropyl bromide 

Downstream Products

• 848192-93-8 3-cyclopropylazetidine-3-ol hydrochloride 
• 1239362-57-2 (S)-4-(3-cyclopropyl-3-methoxyazetidin-1-yl)-N₂-[1-(4-fluorophenyl)ethyl]-N₆-(pyrazin-2-yl)pyridine-2,6-diamine 

Relevant articles and documents

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate

Carboxamide pyrazinyloxy benzoxaboroles were investigated with the goal to identify a molecule with satisfactory antimalarial activity, physicochemical properties, pharmacokinetic profile, in vivo efficacy, and safety profile. This optimization effort discovered 46, which met our target candidate profile. Compound 46 had excellent activity against cultured Plasmodium falciparum, and in vivo against P. falciparum and P. berghei in infected mice. It exhibited good PK properties in mice, rats, and dogs. It was highly active against the other 11 P. falciparum strains, which are mostly resistant to chloroquine and pyrimethamine. The rapid parasite in vitro reduction and in vivo parasite clearance profile of 46 were similar to those of artemisinin and chloroquine, two rapid-acting antimalarials. It was nongenotoxic in an Ames assay, an in vitro micronucleus assay, and an in vivo rat micronucleus assay when dosed orally up to 2000 mg/kg. The combined properties of this novel benzoxaborole support its progression to preclinical development.

TAXANE COMPOUND WITH AZETIDINE RING STRUCTURE

A compound represented by the general formula (1) [X1 and X2 represent hydrogen atom, a halogen atom, hydroxyl group and the like, R1 represents a phenyl group, R2 represents an alkyl group, an alkenyl group, or

AZETIDINYL QUINOLONES AS ANTIBACTERIAL AGENTS

Compounds of formula (I) and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula (I) as well as pharmaceutically acceptable compositions comprising compounds of formula (I). Compoun