848474-61-3Relevant articles and documents
Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide
Machado, Alexandre Legora,Lima, Lidia Moreira,Araujo-Jr, Joao Xavier,Fraga, Carlos Alberto M.,Goncalves Koatz, Vera Lucia,Barreiro, Eliezer J.
, p. 1169 - 1172 (2007/10/03)
As part of an ongoing effort to develop new thalidomide analogues as antiinflammatory lead-candidates, this paper describes the synthesis and antiinflammatory activity of novel N-phenyl-phthalimide functionalized derivatives (4a-d, 5a,b, 6a,b). The target compounds were assayed in an acute lung inflammatory model and all compounds were able to inhibit TNF-α production and subsequent neutrophil recruitment in the LPS-acute lung inflammatory model.