84855-54-9

Basic information

• Product Name: 4β-Isopropylcyclohexane-1α-carbonyl chloride
• Synonyms: 4β-Isopropylcyclohexane-1α-carbonyl chloride
• CAS NO: 84855-54-9
• Molecular Formula: C₁₀H₁₇ClO
• Molecular Weight: 188.69438
• Mol File: 84855-54-9.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4β-Isopropylcyclohexane-1α-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4β-Isopropylcyclohexane-1α-carbonyl chloride(84855-54-9)
• EPA Substance Registry System: 4β-Isopropylcyclohexane-1α-carbonyl chloride(84855-54-9)

Safety Data

• Hazardous Substances Data: 84855-54-9(Hazardous Substances Data)

Upstream product

• 7077-05-6 trans-4-isopropylcyclohexane-1-carboxylic acid 

Downstream Products

• 105816-04-4 nateglinide 

Relevant articles and documents

Palladium-Catalyzed Migratory Insertion of Carbenes and C-C Cleavage of Cycloalkanecarboxamides

A palladium catalyzed reaction of cycloalkanecarboxamides and diazomalonates or bis(phenylsulfonyl)diazomethane has been developed. The reaction proceeds via carbene migratory insertion and cascade C-C cleavage pathways. Cycloalkanecarboxamides with four to seven membered rings are applicable in the transformation. A series of ring opening products were prepared with moderate yields. The finding provides valuable clues for the development of new reactions involving carbene migratory insertion and the cleavage of unstrained C(sp3)-C(sp3) bonds.

A NOVEL AND IMPROVED PROCESS FRO THE PREPARATION OF NATEGLINIDE AND ITS POLYMORPH FORM-H

Nateglinide is prepared by an improved process comprising reaction of trans-4-isopropyl cyclohexane carbonyl chloride with N,O-bis- trimethylsilyl protected D-phenyl alanine to give after aqueous workup, crude nateglinide which is converted to Nateglinide form- H using a mixture of cyclohexane / ethyl acetate. trans-4-isopropyl cyclohexane carbonyl chloride is prepared from trans-4- isopropyl cyclohexane carboxylic acid using oxalyl chloride.