84856-79-1

Basic information

• Product Name: 4-Acetamido-1-(2,3-di-O-acetyl-5-bromo-5-deoxy-β-D-arabinofuranosyl)pyrimidin-2(1H)-one
• Synonyms: 4-Acetamido-1-(2,3-di-O-acetyl-5-bromo-5-deoxy-β-D-arabinofuranosyl)pyrimidin-2(1H)-one
• CAS NO: 84856-79-1
• Molecular Weight: 432.228
• Mol File: 84856-79-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-Acetamido-1-(2,3-di-O-acetyl-5-bromo-5-deoxy-β-D-arabinofuranosyl)pyrimidin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetamido-1-(2,3-di-O-acetyl-5-bromo-5-deoxy-β-D-arabinofuranosyl)pyrimidin-2(1H)-one(84856-79-1)
• EPA Substance Registry System: 4-Acetamido-1-(2,3-di-O-acetyl-5-bromo-5-deoxy-β-D-arabinofuranosyl)pyrimidin-2(1H)-one(84856-79-1)

Safety Data

• Hazardous Substances Data: 84856-79-1(Hazardous Substances Data)

Upstream product

• 32830-01-6 4-Amino-1-(2,5-anhydro-β-D-arabinofuranosyl)pyrimidin-2(1H)-one 

Relevant articles and documents

PREPARATION OF THE 1-(2,5-ANHYDRO-β-D-ARABINOFURANOSYL) DERIVATIVE OF CYTOSINE AND URACIL AND THEIR CLEAVAGE WITH HYDROGEN BROMIDE

Anhydronucleoside Ia was prepared from chloroarabinofuranoxylcytosine IIIc or from 2,2'-anhydro-1-(5-chloro-5-deoxy-β-D-arabinofuranosyl)cytosine by the action of a strongly basic ion exchanger.The anhydro derivative IIa was prepared from 2,2'-anhydro-1-(5-chloro-5-deoxy-β-D-arabinofuranosyl)uracil by treatment with aqueous solution of sodium hydroxide.The action of hydrogen bromide in dimethylformamide on 2',5'-anhydronucleosides Ia and IIa leads both to the cleavage of the anhydro bond under formation of the 5'-bromo derivatives IIIa and IVa and to the cleavage of nucleosidic bond.In case of uracil derivative IIa, the α-arabinofuranosyl derivative V was also isolated after preceding acetylation.For unambiguous proof of the structure, an alternative synthesis of compound V was performed.