848572-61-2Relevant articles and documents
Towards enantioselective nucleophilic trifluoromethylation
Roussel, Solveig,Billard, Thierry,Langlois, Bernard R.,Saint-James, Laurent
, p. 939 - 944 (2007/10/03)
Various trifluoroacetamides and trifluoromethanesulfinamides, derived from chiral silylated amino alcohols, have been synthesized with the goal of achieving enantioselective nucleophilic trifluoromethylation. The best results were obtained with (R)-phenylglycinol derivatives, but the ee values did not exceed 30%.