848576-53-4

Basic information

• Product Name: 1-Boc-4-(5-aminopentyl)piperazine
• Synonyms: 1-Boc-4-(5-aminopentyl)piperazine;4-(5-Aminopentyl)-1-Boc-piperazine 2HCl
• CAS NO: 848576-53-4
• Molecular Formula: C14H29N3O2
• Molecular Weight: 271.4
• Mol File: 848576-53-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 368.823°C at 760 mmHg
• Flash Point: 176.858°C
• Appearance: /
• Density: 1.018g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.491
• CAS DataBase Reference: 1-Boc-4-(5-aminopentyl)piperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-(5-aminopentyl)piperazine(848576-53-4)
• EPA Substance Registry System: 1-Boc-4-(5-aminopentyl)piperazine(848576-53-4)

Safety Data

• Hazardous Substances Data: 848576-53-4(Hazardous Substances Data)

Usage

General Description

1-Boc-4-(5-aminopentyl)piperazine, also known as N-Boc-1-(3-aminopropyl)piperazine, is an organic compound used in the pharmaceutical industry as a building block for the synthesis of various drugs and bioactive compounds. It is a derivative of piperazine, a cyclic amine with important biological and pharmacological properties. The compound has a bulky tert-butyloxycarbonyl (Boc) protecting group at the nitrogen atom and a pentylamine side chain, making it a versatile intermediate for the preparation of a range of potential drug candidates and chemical probes. Its chemical structure and functional groups make it suitable for coupling reactions, functional group manipulations, and other synthetic transformations in drug discovery and development.

InChI:InChI=1/C14H29N3O2/c1-14(2,3)19-13(18)17-11-9-16(10-12-17)8-6-4-5-7-15/h4-12,15H2,1-3H3

Upstream product

• 848576-56-7 tert-butyl 4-(5-(1,3-dioxoisoindolin-2-yl)pentyl)piperazine-1-carboxylate 

Relevant articles and documents

PYRIDINYL DERIVATIVES COMPRISING A CYANOGUANIDINE OR SQUARIC ACID MOIETY

The present application discloses compounds of the formula (I) wherein X = opt.subst. pyrid-3-yl or pyrid-4-yl; Q = opt.subst. Ci-6 alkylene or a single bond; Y is formula (i) wherein D is = N-CN, or formula (ii) B = is opt.subst. C1-6 alkylene; A = (formula) Z = -J-V, wherein J = -C(=0)-, -C(=O)-O, -S(=O)2-, -P(=O)(OR4)-, -C(=O)-NR4- and -C(=S)-NR4-, and V = opt.subst. C1-12-alkyl, opt.subst. C3-12-cycloalkyl, -[CH2CH2O]1-10-( opt.subst. C1-6-alkyl), opt.subst. C1-12- alkenyl, opt.subst. aryl, opt.subst. heterocyclyl, or opt.subst. heteroaryl; q = 0-2, and r = 0- 2; and pharmaceutically acceptable salts thereof, and prodrugs thereof. The application also discloses the compound for use as a medicament for the treatment of a disease or a condition caused by an elevated level of nicotinamide phosphoribosyltransferase (NAMPRT), e.g. inflammatory and tissue repair disorders; dermatosis; autoimmune diseases, Alzheimer's disease, stroke, athersclerosis, restenosis, diabetes, glomerulonephritis, cancer, cachexia, inflammation associated with infection and certain viral infections, including Acquired Immune Deficiency Syndrome (AIDS), adult respiratory distress syndrome, ataxia telengiectasia.