848591-68-4

Basic information

• Product Name: tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate
• Synonyms: tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate
• CAS NO: 848591-68-4
• Molecular Formula: C₁₈H₂₆N₂O₂
• Molecular Weight: 302.41124
• Mol File: 848591-68-4.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate(848591-68-4)
• EPA Substance Registry System: tert - butyl 3 - benzyl - 3,6 - diazabicyclo[3.2.1]octane - 6 - carboxylate(848591-68-4)

Safety Data

• Hazardous Substances Data: 848591-68-4(Hazardous Substances Data)

Upstream product

• 100-46-9 benzylamine 
• 188345-71-3 2-(tert-butoxycarbonyl)-2-azabicyclo[2.2.1]hept-5-ene 
• 24424-99-5 di-tert-butyl dicarbonate 
• 848591-67-3 tert-butyl 2,4-diformylpyrrolidine-1-carboxylate 

Downstream Products

• 194032-49-0 tert-butyl 3,6-diazabicyclo [3.2.1]octane-6-carboxylate 
• 851526-82-4 1-(3-Benzyl-3,6-diazabicyclo[3.2.1]oct-6-yl)-2,2,2-trifluoro-ethanone 
• 851526-81-3 tert-butyl 3,6-diazabicyclo[3.2.1]octane-3-carboxylate 
• 286947-23-7 3-benzyl-3,6-diazabicyclo[3.2.1]octane 

Relevant articles and documents

BRIDGED DIAZEPANE OREXIN RECEPTOR ANTAGONISTS

The present invention is directed to bridged diazepane compounds which are antagonists of orexin receptors. The present invention is also directed to uses of the compounds described herein in the potential treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is also directed to compositions comprising these compounds. The present invention is also directed to uses of these compositions in the potential prevention or treatment of such diseases in which orexin receptors are involved.

Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists

Orexins are neuropeptides that regulate wakefulness and arousal. Small molecule antagonists of orexin receptors may provide a novel therapy for the treatment of insomnia and other sleep disorders. In this Letter we describe the design and synthesis of con

Substituted diazabicycloakane derivatives

Compounds of formula (I) Z-Ar1—Ar2??(I) wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from an unsubstituted or substituted 5-membered heteroaryl ring; an unsubstituted or substituted 6-membered heteroaryl ring; 3,4-(methylenedioxy)phenyl; and phenyl substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.