848750-28-7

Basic information

• Product Name: 1H-Indole, 4-bromo-1,3-dimethyl-2-phenyl-
• CAS NO: 848750-28-7
• Molecular Formula: C16H14BrN
• Molecular Weight: 300.198
• Mol File: 848750-28-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 4-bromo-1,3-dimethyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 4-bromo-1,3-dimethyl-2-phenyl-(848750-28-7)
• EPA Substance Registry System: 1H-Indole, 4-bromo-1,3-dimethyl-2-phenyl-(848750-28-7)

Safety Data

• Hazardous Substances Data: 848750-28-7(Hazardous Substances Data)

Upstream product

• 673-32-5 1-Phenylprop-1-yne 
• 17405-06-0 N-(3-bromophenyl)-N-methylnitrous amide 
• 360575-28-6 2-bromo-6-fluorobenzaldehyde 
• 103-67-3 benzyl-methyl-amine 

Relevant articles and documents

Potassium tert-Butoxide-Mediated Condensation Cascade Reaction: Transition Metal-Free Synthesis of Multisubstituted Aryl Indoles and Benzofurans

An efficient and facile method to synthesize valuable disubstituted 2-aryl indoles and benzofurans in good yields has been demonstrated, based on a tert-butoxide-mediated condensation reaction involving a vinyl sulfoxide intermediate. Products are obtained from N- or O-benzyl benzaldehydes using dimethyl sulfoxide as a carbon source. The methodology features a wide functional group tolerance and transition metal-free environment. Preliminary mechanistic studies suggest that the reaction involves a tandem aldol reaction/Michael addition/dehydrosulfenylation/isomerization sequence through an ionic protocol.

Substituted phenyl indoles

The present invention relates generally to substituted phenyl indoles and methods of using them.