848768-06-9

Basic information

• Product Name: (R)-3-(2-(benzyloxy)-5-Methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aMine
• Synonyms: (R)-3-(2-(benzyloxy)-5-Methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aMine;Benzyl R-(+)-Tolterodine;(3R)-3-(5-methyl-2-phenylmethoxyphenyl)-3-phenyl-N,N-di(propan-2-yl)propan-1-amine
• CAS NO: 848768-06-9
• Molecular Formula: C₂₉H₃₇NO
• Molecular Weight: 415.61018
• Mol File: 848768-06-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (R)-3-(2-(benzyloxy)-5-Methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aMine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-(2-(benzyloxy)-5-Methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aMine(848768-06-9)
• EPA Substance Registry System: (R)-3-(2-(benzyloxy)-5-Methylphenyl)-N,N-diisopropyl-3-phenylpropan-1-aMine(848768-06-9)

Safety Data

• Hazardous Substances Data: 848768-06-9(Hazardous Substances Data)

Usage

Uses

Benzyl R-(+)-Tolterodine is a derivative of Tolterodine (T535795), a muscarinic receptor antagonist that is used to treat patients with overactive bladder.

Upstream product

• 874651-74-8 (R)-3-[2-(benzyloxy)-5-methylphenyl]-3-phenylpropyl 4-nitrobenzenesulfonate 
• 108-18-9 diisopropylamine 
• 863970-29-0 (R)-3-(2-(benzyloxy)-5-methylphenyl)-3-phenylpropanal 
• 827007-19-2 (R)-6-methyl-4-phenyl-3,4-dihydrochromen-2-one 
• 100-39-0 benzyl bromide 
• 156755-35-0 methyl 4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]benzoate 
• 209747-05-7 (S)-2-[3-[bis-(1-methylethyl)-amino]-1-phenylpropyl]-4-methylphenol tartrate 
• 100-44-7 benzyl chloride 
• 124937-52-6 tolterodine tartrate 
• 124937-51-5 (R)-(+)-tolterodine 
• 175647-90-2 (E)-ethyl 3-(2-hydroxy-5-methylphenyl)acrylate 
• 854306-68-6 3-(2-benzyloxy-5-methylphenyl)-3-phenylpropanol 
• 389068-22-8 N,N-diisopropyl-3-(2-benzyloxy-5-methylphenyl)-3-phenylpropylamine 
• 124936-74-9 N,N-diiso-propyl-3-(2-hydroxy-5-methylphenyl)-3-phenylpropanamine 

Downstream Products

• 124937-51-5 (R)-(+)-tolterodine 
• 207679-81-0 (R)-2-[3-(diisopropylamino)-1-phenylpropyl]-4-(hydroxymethyl)-phenol 
• 214601-54-4 (R)-[4-benzyloxy-3-(3-diisopropylamino-1-phenyl-propyl)-phenyl]-methanal 
• 156755-37-2 {4-(benzyloxy)-3-[(1R)-3-(dipropan-2-ylamino)-1-phenylpropyl]phenyl}methanol 

Relevant articles and documents

Rh-Catalyzed Asymmetric Conjugate Addition of Arylboronic Acids to 3-Arylpropenoates: Enantioselective Synthesis of (R)-Tolterodine

A highly enantioselective conjugate addition of arylboronic acids to 3-arylpropenoates is presented. The rhodium complexes obtained from deoxycholic acid derived binaphthyl phosphites showed good activity as well as very high enantioselectivity (ee up to 99 %) in the conjugate addition to different ethyl-3-arylpropenoates, allowing to obtain useful chiral building blocks for the synthesis of active pharmaceutical ingredients. The method was applied to the enantioselective synthesis of the antimuscarinic drug (R)-tolterodine.

Palladium-catalyzed diastereoselective synthesis of β,β-diarylpropionic acid derivatives and its application to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718

Palladium-catalyzed diastereoselective synthesis of optically active β,β-diarylpropionic acid derivatives employing 4-(tert-butyl)oxazolidin-2-one as the chiral auxiliary under an air atmosphere in excellent yields with high diastereoselectivity is reported. The catalytic system is applied to the total synthesis of (R)-tolterodine and the enantiomer of a key intermediate for MK-8718.

DESFESOTERODINE SALTS

The invention relates to substantially pure Desfesoterodine salts, Desfesoterodine salts, solid state forms thereof and pharmaceutical compositions comprising one or more of the Desfesoterodine salts and/or solid state forms thereof.