848852-32-4

Basic information

• Product Name: Benzoic acid, 5-ethenyl-2,3,4-trifluoro-
• Synonyms: 2,3,4-trifluoro-5-vinyl-benzoic acid;2,3,4-TRIFLUORO-VINYL-5-BENZOIC ACID
• CAS NO: 848852-32-4
• Molecular Formula: C9H5F3O2
• Molecular Weight: 202.133
• Mol File: 848852-32-4.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 5-ethenyl-2,3,4-trifluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 5-ethenyl-2,3,4-trifluoro-(848852-32-4)
• EPA Substance Registry System: Benzoic acid, 5-ethenyl-2,3,4-trifluoro-(848852-32-4)

Safety Data

• Hazardous Substances Data: 848852-32-4(Hazardous Substances Data)

Upstream product

• 7486-35-3 tri-n-butyl(vinyl)tin 
• 203916-59-0 2,3,4-trifluoro-5-iodobenzoic acid 
• 61079-72-9 2,3,4,-trifluorobenzoic acid 

Downstream Products

• 848852-33-5 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-vinylbenzoic acid 
• 848852-34-6 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-5-formyl-benzoic acid 
• 874100-39-7 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-5-formyl-N-(2-hydroxyethoxy)benzamide 
• 874100-40-0 5-[1,3]dioxolan-2-yl-3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-benzamide 
• 1293932-54-3 3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-5-vinylbenzamide 
• 848851-55-8 C⁽⁵⁸⁰⁾H₄₈₆₀ 
• 848852-36-8 (E)-3,4-difluoro-2-(2-fluoro-4-trimethylsilanylethynyl-phenylamino)-N-(2-hydroxy-ethoxy)-5-[(2-hydroxy-ethoxyimino)-methyl]-benzamide 
• 1313037-46-5 C₁₉H₁₉F₃IN₃O₄S 
• 874100-62-6 3,4-difluoro-2-(2-fluoro-4-iodo-phenylamino)-N-(2-hydroxy-ethoxy)-5-(methoxyamino-methyl)-benzamide 
• 874100-89-7 C₂₀H₂₀F₃IN₄O₅ 

Relevant articles and documents

NOVEL CRYSTAL FORM OF 3,4-DIFLUORO-2-(2-FLUORO-4-IODO-PHENYL AMINO)-N-(2-HYDROXY-ETHOXY)-5-(3-OXO-[1,2]OXAZINAN-2-YLMETHYL)-BENZAMIDE

PROBLEM TO BE SOLVED: To provide an active pharmaceutical ingredient that is useful as MEK inhibitors and is stable physicochemically. SOLUTION: The present invention provides an educt I-type crystal of 3,4-difluoro-2-(2-fluoro-4-iodo-phenyl amino)-n-(2-hydroxy-ethoxy)-5-(3-oxo-[1,2]oxazinan-2-ylmethyl)-benzamide, having peaks with diffraction angles expressed by 2θ of 14.9, 16.9 and 23.1° (±0.2°) in a powder X-ray diffraction pattern measured using Cu Kα(1.54060?) as an X-ray source. SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT

Beyond the MEK-pocket: Can current MEK kinase inhibitors be utilized to synthesize novel type III NCKIs? Does the MEK-pocket exist in kinases other than MEK?

An approach and preliminary results for utilizing legacy MEK inhibitors as templates for a reiterative structural based design and synthesis of novel, type III NCKIs (non-classical kinase inhibitors) is described. Evidence is provided that the MEK-pocket

NOVEL 4-PHENYLAMINO-BENZALDOXIME DERIVATIVE AND USE THEREOF AS MEK INHIBITOR

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