849098-26-6

Basic information

• Product Name: 2H-Indol-2-one, 4-chloro-1,3-dihydro-1-(phenylmethyl)-
• CAS NO: 849098-26-6
• Molecular Formula: C15H12ClNO
• Molecular Weight: 257.719
• Mol File: 849098-26-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 4-chloro-1,3-dihydro-1-(phenylmethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 4-chloro-1,3-dihydro-1-(phenylmethyl)-(849098-26-6)
• EPA Substance Registry System: 2H-Indol-2-one, 4-chloro-1,3-dihydro-1-(phenylmethyl)-(849098-26-6)

Safety Data

• Hazardous Substances Data: 849098-26-6(Hazardous Substances Data)

Upstream product

• 6575-24-2 2-(2,6-dichlorophenyl)acetic acid 
• 100-46-9 benzylamine 
• 1017609-57-2 1-benzyl-4-chloroindoline-2,3-dione 
• 620-05-3 iodomethylbenzene 
• 6344-05-4 4-chloroisatin 
• 100-39-0 benzyl bromide 

Downstream Products

• 1017609-54-9 1-benzyl-4-chloro-3-(3-methoxyphenyl)indolin-2-one 
• 1361017-49-3 C₂₄H₁₆ClNO 

Relevant articles and documents

Cinchona-alkaloid-catalyzed enantioselective hydroxymethylation of 3-fluorooxindoles with paraformaldehyde

Cinchona-alkaloid-catalyzed hydroxymethylation of 3-fluorooxindoles using paraformaldehyde as the C1 unit was achieved. A wide range of 3-fluorooxindoles was successfully reacted to give the corresponding 3-fluoro-3-hydroxymethyloxindoles with high efficiency and moderate to good enantioselectivity.

Enantioselective Synthesis of Multisubstituted Spirocyclopentane Oxindoles Enabled by Pd/Chiral Rh(III) Complex Synergistic Catalysis

An asymmetric [3 + 2]-cycloaddition reaction of α,β-unsaturated 2-acyl imidazoles with spirovinylcyclopropanyl-2-oxindoles catalyzed synergistically by an achiral palladium(0) catalyst and a chiral-at-metal rhodium(III) complex has been developed. A series of biologically important 3-spirocyclopentane-2-oxindoles with four contiguous stereocenters were synthesized in high yields (up to 99%) with excellent stereoselectivities (up to 99% ee, 20:1 dr).

Microwave-assisted sequential amide bond formation and intramolecular amidation: A rapid entry to functionalized oxindoles

(Chemical Equation Presented) A general method has been developed for the synthesis of N-substituted oxindoles. The two-step process involves initial microwave-assisted amide bond formation between 2-halo-arylacetic acids and various alkylamines and anilines, followed by a palladium-catalyzed intramolecular amidation under aqueous conditions. In the case of alkylamines, the procedure can be carried out as a one-pot process without isolation of the intermediate amide.