849335-07-5

Basic information

• Product Name: Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, monohydrochloride
• CAS NO: 849335-07-5
• Molecular Formula: C9H8ClF3N4.ClH
• Molecular Weight: 301.098
• Mol File: 849335-07-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, monohydrochloride(849335-07-5)
• EPA Substance Registry System: Hydrazinecarboximidamide, 2-[[4-chloro-3-(trifluoromethyl)phenyl]methylene]-, monohydrochloride(849335-07-5)

Safety Data

• Hazardous Substances Data: 849335-07-5(Hazardous Substances Data)

Upstream product

• 34328-47-7 4-dibromo-3-(trifluoromethyl)benzaldehyde 
• 1937-19-5 1-aminoguanidine hydrochloride 
• 34328-46-6 4-chloro-3-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

Aminoguanidine hydrazone derivatives as non-peptide NPFF1 receptor antagonists reverse opioid induced hyperalgesia

Neuropeptide FF receptors (NPFF1R and NPFF2R) and their endogenous ligand Neuropeptide FF have been shown previously to display anti-opioid properties and to play a critical role in the adverse effects associated with chronic administrations of opiates including the development of opioid-induced hyperalgesia and analgesic tolerance. In this work, we sought to identify novel NPFF receptors ligands by focusing our interest on a series of heterocycles as rigidified non-peptide NPFF receptor ligands, starting from already described aminoguanidine hydrazones (AGH's). Binding experiments and functional assays highlighted AGH 1n and its rigidified analog 2-amino-dihydropyrimidine 22e for in vivo experiments. As earlier shown with the prototypical dipeptide antagonist RF9, both 1n and 22e reduced significantly the long lasting fentanyl-induced hyperalgesia in rodents. Altogether these data indicate that AGH rigidification maintains nanomolar affinities for both NPFF receptors, while improving antagonist character towards NPFF1R.