849345-43-3

Basic information

• Product Name: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chloro-7-quinazolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4S)-
• CAS NO: 849345-43-3
• Molecular Formula: C19H22ClN3O5
• Molecular Weight: 407.854
• Mol File: 849345-43-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chloro-7-quinazolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chloro-7-quinazolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4S)-(849345-43-3)
• EPA Substance Registry System: 1,2-Pyrrolidinedicarboxylic acid, 4-[(4-chloro-7-quinazolinyl)oxy]-, 1-(1,1-dimethylethyl) 2-methyl ester, (2S,4S)-(849345-43-3)

Safety Data

• Hazardous Substances Data: 849345-43-3(Hazardous Substances Data)

Upstream product

• 849345-42-2 4-chloro-7-hydroxyquinazoline 
• 74844-91-0 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate 

Downstream Products

• 849345-44-4 methyl (4S)-4-({4-[(3-chloro-2-fluorophenyl)amino]quinazolin-7-yl}oxy)-L-prolinate 

Relevant articles and documents

QUINAZOLINE DERIVATIVES

The invention concerns a quinazoline derivative of the Formula (I): wherein each of the variables have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours which are sensitive to inhibition of erbB receptor tyrosine kinases.