849455-40-9

Basic information

• Product Name: C₁₂H₁₀ClFN₂OS
• Synonyms: C₁₂H₁₀ClFN₂OS
• CAS NO: 849455-40-9
• Molecular Weight: 284.742
• Mol File: 849455-40-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₀ClFN₂OS(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₀ClFN₂OS(849455-40-9)
• EPA Substance Registry System: C₁₂H₁₀ClFN₂OS(849455-40-9)

Safety Data

• Hazardous Substances Data: 849455-40-9(Hazardous Substances Data)

Upstream product

• 1694-29-7 3-chloropentane-2,4-dione 
• 154371-25-2 1-(3-chloro-4-fluorophenyl)thiourea 
• 123-54-6 acetylacetone 

Downstream Products

• 1257438-85-9 1-[2-(3-chloro-4-fluorophenylamino)-4-methyl-thiazole-5-yl]-3-(3,4,5-trimethoxyphenyl)-propen-1-one 
• 1333391-37-9 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-N-phenylamine 
• 1333391-38-0 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-m-tolylamine 
• 1333391-40-4 (4-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}pyrimidin-2-yl)-o-tolylamine 
• 1333391-59-5 3-dimethylamino-1-{2-[(3-chloro-4-fluorophenyl)(methyl)amino]-4-methylthiazol-5-yl}propenone 

Relevant articles and documents

Synthesis of novel thiazolyl-pyrimidines and their anticancer activity in vitro

A series of novel compounds 7-43 were prepared via the condensation of enaminones 4a-h and the guanidines carbonate 6a-f. The structures of these newly synthesized compounds were confirmed by 1H-NMR, MS, EA and IR. All the compounds were tested for their cytotoxic activity in vitro against human cancer cell lines including Ishikawa, A549, BEL-7404, SPC-A-01 and SGC-7901. Most of them showed moderate cytotoxic against the tested cell lines. Among them, the most potent compounds 9 and 30 exhibited more efficient activity against Ishikawa, A549. Thiazolyl-pyrimidines were synthesized by the general pyrimidine condensation of Bredereck and their in-vitro anticancer activities were evaluated. Copyright