849472-67-9Relevant articles and documents
Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions
Ovadia, Reuben,Lebrun, Aurélien,Barvik, Ivan,Vasseur, Jean-Jacques,Baraguey, Carine,Alvarez, Karine
, p. 11052 - 11071 (2015)
A solution phase synthesis of peptide nucleic acid monomers and dimers was developed by using microwave-promoted Ugi multicomponent reactions. A mixture of a functionalized amine, a carboxymethyl nucleobase, paraformaldehyde and an isocyanide as building blocks generates PNA monomers which are then partially deprotected and used in a second Ugi 4CC reaction, leading to PNA dimers. Conformational rotamers were identified by using NMR and MD simulations.