849480-05-3

Basic information

• Product Name: (1R)-1-cyclohexyl-1-[(2S)-2,3-dihydro-1H-indol-2-yl]-2-methoxyethanol
• Synonyms: (1R)-1-cyclohexyl-1-[(2S)-2,3-dihydro-1H-indol-2-yl]-2-methoxyethanol
• CAS NO: 849480-05-3
• Molecular Weight: 275.391
• Mol File: 849480-05-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1R)-1-cyclohexyl-1-[(2S)-2,3-dihydro-1H-indol-2-yl]-2-methoxyethanol(CAS DataBase Reference)
• NIST Chemistry Reference: (1R)-1-cyclohexyl-1-[(2S)-2,3-dihydro-1H-indol-2-yl]-2-methoxyethanol(849480-05-3)
• EPA Substance Registry System: (1R)-1-cyclohexyl-1-[(2S)-2,3-dihydro-1H-indol-2-yl]-2-methoxyethanol(849480-05-3)

Safety Data

• Hazardous Substances Data: 849480-05-3(Hazardous Substances Data)

Upstream product

• 500548-61-8 tert-butyl (2S)-2-(methoxyacetyl)indoline-1-carboxylate 
• 849479-89-6 tert-butyl (2S)-2-{[methoxy(methyl)amino]carbonyl}indoline-1-carboxylate 
• 197460-36-9 methyl (S)-N-(tert-butoxycarbonyl)indoline-2-carboxylate 
• 141410-06-2 (S)-indoline-2-carboxylic acid methyl ester 
• 79815-20-6 (S)-indoline-2-carboxylic acid 

Relevant articles and documents

Stereospecific synthesis of 2,2,3-trisubstituted tetrahydroquinolines: Application to the total syntheses of benzastatin E and natural virantmycin

An efficient methodology for the synthesis of 2,2,3-trisubstituted tetrahydroquinolines has been developed, which involves the triphenylphosphine- CCl4-mediated stereospecific rearrangement of α,α- disubstituted indoline-2-methanols 15 to 2,2,3-trisubstituted tetrahydroquinolines 26. The rearrangement precursors 15 are readily prepared by the diastereoselective Grignard addition to 2-acylindolines 13. The total syntheses of (+)-benzastatin E (1) and natural virantmycin (2a) were accomplished utilizing this methodology. This rearrangement reaction might afford some chemical precedent for the biogenetic pathway of the benzastatin family.