849773-54-2Relevant articles and documents
Buchwald-Hartwig versus Microwave-Assisted Amination of Chloroquinolines: En Route to the Pyoverdin Chromophore
Altevogt, Luca,Baro, Angelika,Bilitewski, Ursula,Freund, Marcel,Laschat, Sabine,Lin, Yulin,Rudolf, Richard,Seubert, Philipp
, p. 1177 - 1181 (2020/07/20)
The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80percent, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2 R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.
Total synthesis of pyoverdin D
Mashiach, Roi,Meijler, Michael M.
supporting information, p. 1702 - 1705 (2013/06/27)
Pyoverdin D is an important siderophore that is used by the human pathogen Pseudomonas aeruginosa to import iron and gain a competitive advantage. This unique partially cyclic octapeptide bears four nonproteinogenic amino acids, including δN-formyl-δN-hydroxy-l-ornithine, and a catechol containing chiral chromophore. Here, we report the first total synthesis of pyoverdin D.
Compounds having aryl-sulphonamidic structure useful as metalloproteases inhibitors
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Page/Page column 19, (2008/12/08)
The invention relates to aryl-sulphonamido compounds endowed with inhibitory activity against metallo proteases MMP, having formula (I) below wherein R, R1, R2, R3, R4, R5, n and m have the meanings r