849791-82-8

Basic information

• Product Name: (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate
• Synonyms: (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate
• CAS NO: 849791-82-8
• Molecular Weight: 527.701
• Mol File: 849791-82-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate(849791-82-8)
• EPA Substance Registry System: (20R)-3α-(2'-methoxyethoxy)methoxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate(849791-82-8)

Safety Data

• Hazardous Substances Data: 849791-82-8(Hazardous Substances Data)

Upstream product

• 849791-75-9 (20R)-6α-bromo-5-hydroxy-7-nor-5β-pregnane-3β,20-diyl 3-acetate 20-benzoate 
• 849791-80-6 (20R)-6-aza-7-oxo-5α-pregnane-3β,20-diyl 3-mesylate 20-benzoate 
• 849791-76-0 (20R)-5,6β-epoxy-3β-hydroxy-7-nor-5β-pregnan-20-yl benzoate 
• 251984-45-9 (20R)-7-Norpregn-5-ene-3β,20-diyl 3-acetate 20-benzoate 
• 3970-21-6 2-Methoxyethoxymethyl chloride 
• 849791-81-7 (20R)-3α-hydroxy-6-aza-7-oxo-5α-pregnan-20-yl benzoate 

Relevant articles and documents

Neurosteroid analogues: Synthesis of 6-aza-allopregnanolone

An efficient synthesis of 6-azapregnane derivatives and their biological activity is described. The nitrogen was introduced into the B ring using Beckmann rearrangement of the (E)-oxime of 6-oxo-B-nor-5α-pregnane derivatives. The required 3α-hydroxyl was produced either by solvolysis of the corresponding 3β-mesyloxy group or by the Meerwein-Ponndorf-Verley reduction of the 3-oxo group; this reduction could be carried out selectively with an unprotected 3,20-dioxo derivative. The binding of the 6-aza-steroids to the γ-aminobutyric acid receptor (GABAA) was measured using [35S]-tert-butyl-bicyclo[2.2.2]phosphorothionate (TBPS) and [ 3H]flunitrazepam. The only analogue to be slightly active was that lacking any oxygen function in position 3.