849903-79-3

Basic information

• Product Name: 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-
• Synonyms: 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-;3-ethyl-9-hydroxy-2-Methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyriMidin-4-one;4H-Pyrido[1,2-a]pyriMidin...;Paliperidone Stage III (USP RC A);3-Ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one;Paliperidone Related CoMpound A;Paliperidone Related Compound A (20 mg) (3-Ethyl-9-hydroxy-2-methyl-6,7,8,9-tetrahydro-4H-pyrido[1,2-alpha]pyrimidin-4-one);3-ethyl-9-hydroxy-2-methyl-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-4-one
• CAS NO: 849903-79-3
• Molecular Formula: C₁₁H₁₆N₂O₂
• Molecular Weight: 208.25694
• Mol File: 849903-79-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 349.0±44.0 °C(Predicted)
• Appearance: /
• Density: 1.29±0.1 g/cm3(Predicted)
• PKA: 13.01±0.60(Predicted)
• CAS DataBase Reference: 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-(849903-79-3)
• EPA Substance Registry System: 4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methyl-(849903-79-3)

Safety Data

• Hazardous Substances Data: 849903-79-3(Hazardous Substances Data)

Usage

Description

4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methylis a chemical compound that serves as an intermediate in the synthesis of Paliperidone (P141000), a medication used for the treatment of schizophrenia and other mental health disorders.
Used in Pharmaceutical Industry:
4H-Pyrido[1,2-a]pyriMidin-4-one, 3-ethyl-6,7,8,9-tetrahydro-9-hydroxy-2-Methylis used as an intermediate in the synthesis of Paliperidone (P141000) for its role in the treatment of schizophrenia and other mental health disorders. It plays a crucial role in the production process, enabling the creation of an effective medication to manage these conditions.

Upstream product

• 147687-17-0 9-(benzyloxy)-3-(2-chloroethyl)-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one 
• 849727-62-4 3-(2-chloroethyl)-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one monohydrochloride 
• 517-23-7 3-acetyl-2-oxo-4,5-dihydrofuran 
• 16867-03-1 2-amino-3-hydroxypyridine 

Relevant articles and documents

Oxidative degradation of paliperidone using potassium permangnate in acid medium

Oxidative degradation reactions of paliperidone are studied using potassium permanganate in acidic medium spectrophotometrically. Complete reaction was carried out in pseudo first order condition. The reaction orders were calculated with respect to the paliperidone and acid, the obtained values indicate that these reactant have less than first order dependency on the reaction rate. Oxidation products were identified using LC-MS technique and their m/z values were found to be 207, 221 and 443. Kinetics and the mechanism of the reactions were derived from the results identified. The reactions were studied at four different temperatures with different paliperidone and acid concentrations. The activation and thermodynamic parameters were calculated by graphical method.

A PROCESS FOR THE PREPARATION OF PALIPERIDONE INTERMEDIATES

The present invention relates to a process for the preparation of 3-(2-chloroethyl)-6, 7, 8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[1,2-a]-pyrimidin-4-one; and its use in the synthesis of paliperidone.