849935-85-9

Basic information

• Product Name: (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate
• Synonyms: (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate
• CAS NO: 849935-85-9
• Molecular Formula: C12H21NO5
• Molecular Weight: 259.3
• Mol File: 849935-85-9.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 400.051 °C at 760 mmHg
• Flash Point: 195.744 °C
• Appearance: /
• Density: 1.222g/cm³
• Vapor Pressure: 4.61E-08mmHg at 25°C
• Refractive Index: 1.512
• PKA: 14.07±0.40(Predicted)
• CAS DataBase Reference: (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate(849935-85-9)
• EPA Substance Registry System: (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate(849935-85-9)

Safety Data

• Hazardous Substances Data: 849935-85-9(Hazardous Substances Data)

Usage

Description

(3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate is a chiral organic compound characterized by its specific stereochemistry and functional groups. It features a pyrrolidine ring with a hydroxyl group and two carboxylate groups, as well as a tert-butyl and an ethyl substituent. (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate is known for its potential applications in the synthesis of biologically active molecules.

Uses

Used in Pharmaceutical Industry:
(3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate is used as an intermediate in the preparation of various substituted fused quadracyclic compounds. These compounds are of interest due to their potential as inhibitors of MK2, a kinase enzyme involved in inflammatory and stress response pathways. By targeting MK2, these quadracyclic compounds may offer therapeutic benefits in treating conditions associated with excessive inflammation or cellular stress.
Additionally, the chiral nature and unique functional groups of (3S,4R)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate make it a valuable building block for the development of other pharmaceutical agents with specific biological activities. Its use in the synthesis of such compounds can lead to the discovery of new drugs with improved efficacy and selectivity.

InChI:InChI=1/C12H21NO5/c1-5-12(9(15)16)7-13(6-8(12)14)10(17)18-11(2,3)4/h8,14H,5-7H2,1-4H3,(H,15,16)/t8-,12-/m0/s1

Upstream product

• 146256-98-6 4-oxo-pyrrolidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester 
• 108-05-4 vinyl acetate 
• 1523541-94-7 (trans)-1-tert-butyl 3-ethyl 4-hydroxypyrrolidine-1,3-dicarboxylate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 1378850-15-7 C₇H₁₃NO₃ 

Relevant articles and documents

TLR2 MODULATOR COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

The present disclosure relates to compounds which modulate the activity of Toll-like receptor (TLR) proteins, including agonists or activators, partial agonists, and antagonists. Of particular interest of compounds that modulate the activity of TLR2, as well as methods of using such compounds to treat cancer and other disorders associated with a TLR2 pathway.

Synthesis, antimycobacterial and antibacterial activity of fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety

A series of novel fluoroquinolone derivatives containing an 3-alkoxyimino-4-(cyclopropylanimo)methylpyrrolidine moiety were designed, synthesized and evaluated for their biological activity. Our results revealed that 19b2 shows good activity against MTB H

Peptides containing an arginine mimetic for the treatment of bone metabolic disorders, their production, and drugs containing these compounds

Arginine mimetic peptides according to Formula I of this application have a stimulating effect on bone formation and are useful for the treatment of bone metabolic disorders.