849937-90-2 Usage
General Description
2,4-Difluoropyridine-3-carboxylic acid is a chemical compound with the molecular formula C6H3F2NO2. It is a derivative of pyridine and is known for its fluorinated structure. 2,4-Difluoropyridine-3-carboxylic acid is commonly used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and materials. It has been studied for its potential antiviral and anticancer properties, and has also been investigated for its use in the development of new drugs and treatments. 2,4-Difluoropyridine-3-carboxylic acid is an important intermediate in the chemical industry and has applications in various fields of research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 849937-90-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,4,9,9,3 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 849937-90:
(8*8)+(7*4)+(6*9)+(5*9)+(4*3)+(3*7)+(2*9)+(1*0)=242
242 % 10 = 2
So 849937-90-2 is a valid CAS Registry Number.
849937-90-2Relevant articles and documents
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: The trialkylsilyl trick
Schlosser, Manfred,Bobbio, Carla,Rausis, Thierry
, p. 2494 - 2502 (2005)
(Chemical Equation Presented) 2,4-Difluoropyridine, 2,4-dichloropyridine, 2,4,6-trifluoropyridine, 2,4,6-trichloropyridine and 2,3,4,6-tetrafluoropyridine react with standard nucleophiles exclusively at the 4-position under halogen displacement. However, the regioselectivity can be completely reversed if a trialkylsilyl group is introduced in the 5-position of the 2,4-dihalopyridines or in the 3-position of the 2,4,6-trihalopyridines or 2,3,4,6-tetrahalopyridine. Then only the halogen most remote from the bulky silyl unit (at the 2-position in the case of the 2,4-halopyridines, at the 6-position with the other substrates) gets involved in the exchange process. After removal of the silyl protective group the nucleophile is invariably found to occupy the nitrogen-neighboring position.
