85-57-4Relevant articles and documents
Hubacher
, p. 718 (1946)
Preparation method of 2-(4-hydroxybenzoyl)benzoic acid
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Paragraph 0028; 0032; 0036, (2017/07/20)
The invention belongs to the technical fields of fine chemical engineering and preparation of drug intermediates, and particularly relates to a preparation method of 2-(4-hydroxybenzoyl)benzoic acid. The preparation method comprises the following steps: heating and refluxing anisole and phthalic anhydride under the action of a Lewis acid catalyst to conduct a friedel-crafts acylation reaction to obtain an intermediate 2-(4-methoxybenzoyl) benzoic acid, then heating and refluxing under the action of a hydrobromic acid solution to sufficiently react to prepare the 2-(4-hydroxybenzoyl)benzoic acid of the target product. Compared with the prior art, the prepared 2-(4-hydroxybenzoyl)benzoic acid is good in quality and higher in yield, and the preparation method is simple in preparation process, mild in conditions, low in energy consumption, low in cost and suitable for mass production.
Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging
Yang, Lingfei,Zhu, Yuanjun,Shui, Mengyang,Zhou, Tongliang,Cai, Yuanbo,Wang, Wei,Xu, Fengrong,Niu, Yan,Wang, Chao,Zhang, Jun-Long,Xu, Ping,Yuan, Lan,Liang, Lei
, p. 12363 - 12370 (2016/08/24)
Phthalazinone derivatives were designed as optical probes for one- and two-photon fluorescence microscopy imaging. The design strategy involves stepwise extension and modification of pyridazinone by 1) expansion of pyridazinone to phthalazinone, a larger conjugated system, as the electron acceptor, 2) coupling of electron-donating aromatic groups such as N,N-diethylaminophenyl, thienyl, naphthyl, and quinolyl to the phthalazinone, and 3) anchoring of an alkyl chain to the phthalazinone with various terminal substituents such as triphenylphosphonio, morpholino, triethylammonio, N-methylimidazolio, pyrrolidino, and piperidino. Theoretical calculations were utilized to verify the initial design. The desired fluorescent probes were synthesized by two different routes in considerable yields. Twenty-two phthalazinone derivatives were synthesized and their photophysical properties were measured. Selected compounds were applied in cell imaging, and valuable information was obtained. Furthermore, the designed compounds showed excellent performance in two-photon microscopic imaging of mouse brain slices.