85-58-5

Basic information

• Product Name: BENZOPHENONE-2,4'-DICARBOXYLIC ACID
• Synonyms: 2,4-CARBONYLDIBENZOIC ACID;2,4'-BENZOPHENONEDICARBOXYLIC ACID;2,4'-DICARBOXY BENZOPHENONE;BENZOPHENONE-2,4'-DICARBOXYLIC ACID;Benzophenone-2,4-dicarboxilic acid;Benzophenonedicarboxilicacid;BENZOPHENONE-2,4'-DICARBOXYLIC ACID 1-HYDRATE;NSC5003
• CAS NO: 85-58-5
• Molecular Formula: C₁₅H₁₀O₅
• Molecular Weight: 270.24
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);Benzophenones (for High-Performance Polymer Research);Functional Materials;Reagent for High-Performance Polymer Research
• Mol File: 85-58-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 241 °C
• Boiling Point: 556.6±35.0 °C(Predicted)
• Appearance: /
• Density: 1.403±0.06 g/cm3(Predicted)
• Solubility: almost transparency in Methanol
• PKA: 3.23±0.36(Predicted)
• CAS DataBase Reference: BENZOPHENONE-2,4'-DICARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: BENZOPHENONE-2,4'-DICARBOXYLIC ACID(85-58-5)
• EPA Substance Registry System: BENZOPHENONE-2,4'-DICARBOXYLIC ACID(85-58-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 85-58-5(Hazardous Substances Data)

Usage

General Description

Benzophenone-2,4'-dicarboxylic acid is a chemical compound belonging to the class of organic compounds known as benzoic acids and derivatives. These are compounds containing a benzoic acid moiety, in which the carboxyl group is attached to a benzene ring. The compound is primarily characterized by the presence of two carboxylic acid functional groups in the 2 and 4' positions of the benzophenone structure. This chemical is generally a white crystalline powder at room temperature and possesses aromatic, acidic characteristics. It is primarily used in scientific research and potentially for manufacturing different types of resins, pharmaceuticals, and polymers.

Upstream product

• 1140-16-5 (2-methylphenyl)(4-methylphenyl)methanone 
• 85-55-2 2-(4-toluoyl)benzoic acid 
• 65414-25-7 4-(2-methylbenzoyl)benzoic acid 
• 82101-39-1 4-(p-tolyl)-1-tetralone 
• 19772-67-9 2-Chlor-3-(4-tolyl)-indenon-⁽¹⁾ 
• 42797-18-2 2-(4-phenylbenzoyl)benzoic acid 
• 64-19-7 acetic acid 
• 932-31-0 ortho-tolylmagnesium bromide 
• 100-20-9 terephthaloyl chloride 

Downstream Products

• 203626-27-1 2,4'-carbonyl-di-benzoic acid dimethyl ester 
• 6268-08-2 2,4'-methanediyl-di-benzoic acid 
• 152567-94-7 4-(4-Oxo-3,4-dihydro-phthalazin-1-yl)-benzoic acid 
• 117-78-2 anthraquinone-2-carboxylic acid 
• 100-21-0 terephthalic acid 
• 65-85-0 benzoic acid 
• 152567-95-8 4-(4-Oxo-3,4-dihydro-phthalazin-1-yl)-benzoic acid ethyl ester 
• 152567-72-1 4-[3-(2-Imidazol-1-yl-ethyl)-4-oxo-3,4-dihydro-phthalazin-1-yl]-benzoic acid ethyl ester 
• 1401685-99-1 [Zn(2-(4-pyridyl)benzimidazole)(benzophenone-2,4'-dicarboxylate)]n 

Relevant articles and documents

Synthesis, Cytotoxicity, and Mechanistic Investigation of Platinum(IV) Anticancer Complexes Conjugated with Poly(ADP-ribose) Polymerase Inhibitors

Many clinical trials using combinations of platinum drugs and PARP-1 inhibitors (PARPi) have been carried out, with the hope that such combinations will lead to enhanced therapeutic outcomes against tumors. Herein, we obtained seven potential PARPi with structural diversity and then conjugated them with cisplatin-based platinum(IV) complexes. Both the synthesized PARPi ligands and PARPi-Pt conjugates [PARPi-Pt(IV)] show inhibitory effects against PARP-1's catalytic activity. The PARPi-Pt(IV) conjugates are cytotoxic in a panel of human cancer cell lines, and the leading ones display the ability to overcome cisplatin resistance. A mechanistic investigation reveals that the representative PARPi-Pt(IV) conjugates efficiently enter cells, bind to genomic DNA, disturb cell cycle distribution, and induce apoptotic cell death in both cisplatin-sensitive and-resistant cells. Our study provides a strategy to improve the cytotoxicity of platinum(IV)-based anticancer complexes and overcome cisplatin resistance by using a small-molecule anticancer complex that simultaneously damages DNA and inhibits PARP.