85028-46-2

Basic information

• Product Name: (1,1-Dimethyl-but-3-ynyl)-phenyl-amine
• Synonyms: (1,1-Dimethyl-but-3-ynyl)-phenyl-amine
• CAS NO: 85028-46-2
• Molecular Weight: 173.258
• Mol File: 85028-46-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (1,1-Dimethyl-but-3-ynyl)-phenyl-amine(CAS DataBase Reference)
• NIST Chemistry Reference: (1,1-Dimethyl-but-3-ynyl)-phenyl-amine(85028-46-2)
• EPA Substance Registry System: (1,1-Dimethyl-but-3-ynyl)-phenyl-amine(85028-46-2)

Safety Data

• Hazardous Substances Data: 85028-46-2(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 1124-52-3 N-(propan-2-ylidene)aniline 
• 18295-60-8 propargyl magnesium bromide 

Relevant articles and documents

Silver-Catalyzed Three-Component 1,1-Aminoacylation of Homopropargylamines: α-Additions for Both Terminal Alkynes and Isocyanides

The reaction of secondary homopropargylamines, isocyanides, and water in the presence of a catalytic amount of silver acetate and subsequent purification by chromatography on silica gel afforded substituted proline amides in good to excellent yields. Primary homopropargylamines underwent a cyclizative Ugi–Joullié three-component reaction with isocyanides and carboxylic acids to afford functionalized N-acyl proline amides. High diastereoselectivity was observed in the synthesis of 4-alkoxy and 4,5-disubstituted proline derivatives. This work represents the first examples of a three-component cyclizative 1,1-aminoacylation of terminal alkynes.