850563-45-0

Basic information

• Product Name: 2-FLUORO-3-METHOXYBENZOYL CHLORIDE
• Synonyms: 2-FLUORO-3-METHOXYBENZOYL CHLORIDE;2-Fluoro-3-methoxybenzoyl chloride 97%;2-Fluoro-3-methoxybenzoylchloride97%;3-(Chlorocarbonyl)-2-fluoroanisole
• CAS NO: 850563-45-0
• Molecular Formula: C₈H₆ClFO₂
• Molecular Weight: 188.58
• Mol File: 850563-45-0.mol
• Article Data: 3

Chemical Properties

• Melting Point: 49-51
• Boiling Point: 133/12mm
• Flash Point: 106.6°C
• Appearance: /
• Density: 1.309g/cm³
• Vapor Pressure: 0.0296mmHg at 25°C
• Refractive Index: 1.511
• Sensitive: Moisture Sensitive/Lachrymatory
• CAS DataBase Reference: 2-FLUORO-3-METHOXYBENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-METHOXYBENZOYL CHLORIDE(850563-45-0)
• EPA Substance Registry System: 2-FLUORO-3-METHOXYBENZOYL CHLORIDE(850563-45-0)

Safety Data

• Hazard Codes: C
• Hazardous Substances Data: 850563-45-0(Hazardous Substances Data)

Usage

General Description

2-FLUORO-3-METHOXYBENZOYL CHLORIDE is a chemical compound with the molecular formula C8H6ClFO2. It is a benzoic acid derivative with a fluorine atom and a methoxy group attached to the benzene ring. 2-FLUORO-3-METHOXYBENZOYL CHLORIDE is classified as a chloroformyl chloride, meaning it contains a carbon atom bonded to a chlorine atom and a carbonyl group. 2-FLUORO-3-METHOXYBENZOYL CHLORIDE is commonly used in organic synthesis as a reagent for the introduction of the benzoic acid functionality into various organic molecules. It is also utilized as an intermediate in the pharmaceutical and agrochemical industries for the production of various drugs and pesticides. Additionally, it is a key building block for the development of novel materials and compounds for research and industrial applications.

InChI:InChI=1/C8H6ClFO2/c1-12-6-4-2-3-5(7(6)10)8(9)11/h2-4H,1H3

Upstream product

• 137654-20-7 2-fluoro-3-methoxybenzoic acid 

Downstream Products

• 1022159-33-6 2-fluoro-3-methoxybenzoyl azide 
• 198204-64-7 2-fluoro-3-methoxybenzamide 
• 1361252-90-5 2-fluoro-3-hydroxy-N-(6-hydroxy-1,3-benzothiazol-2-yl)benzamide 
• 1361253-24-8 2-fluoro-3-methoxy-N-(6-methoxy-1,3-benzothiazol-2-yl)benzamide 

Relevant articles and documents

Site-Selective Silylation of Aliphatic C-H Bonds Mediated by [1,5]-Hydrogen Transfer: Synthesis of α-Sila Benzamides

The first example of site-selective silylation of C(sp3)-H bonds mediated by a [1,5]-hydrogen transfer is reported. This reaction occurs selectively at the α-position of benzamides with a combination of tert-butylmagnesium chloride and a catalytic amount of 4,4′-di-tert-butylbipyridine (dtbpy) ligand and provides a facile route for the creation of biologically interesting α-sila benzamides. Late-stage functionalization of the incorporated silyl moieties facilitates the synthesis of N-formyl, cis-enamine, β-hydroxyl, amino, and pyrrole-containing derivatives.

HETEROARYL COMPOUNDS, COMPOSITIONS THEREOF, AND USE THEREOF AS PROTEIN KINASE INHIBITORS

Provided herein are Heteroaryl Compounds having the following structure: (I) wherein R1, R2, L, X, Y, Z, Q, A and B are as defined herein, compositions comprising an effective amount of a Heteroaryl Compound and methods for treating or preventing cancer, inflammatory conditions, immunological conditions, metabolic conditions and conditions treatable or preventable by inhibition of a kinase pathway comprising administering an effective amount of a Heteroaryl Compound to a patient in need thereof.