85063-55-4

Basic information

• Product Name: N-(4-methoxyphenyl)-6-methylbenzo[d]thiazol-2-amine
• Synonyms: N-(4-methoxyphenyl)-6-methylbenzo[d]thiazol-2-amine
• CAS NO: 85063-55-4
• Molecular Weight: 270.355
• Mol File: 85063-55-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-(4-methoxyphenyl)-6-methylbenzo[d]thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)-6-methylbenzo[d]thiazol-2-amine(85063-55-4)
• EPA Substance Registry System: N-(4-methoxyphenyl)-6-methylbenzo[d]thiazol-2-amine(85063-55-4)

Safety Data

• Hazardous Substances Data: 85063-55-4(Hazardous Substances Data)

Upstream product

• 3507-26-4 2-chloro-6-methylbenzo[d]thiazole 
• 104-94-9 4-methoxy-aniline 
• 1397746-41-6 C₁₅H₁₅IN₂OS 
• 583-68-6 2-bromo-p-toluidine 
• 2284-20-0 4-Methoxyphenyl isothiocyanate 
• 29289-13-2 2-iodo-4-methylaniline 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 

Relevant articles and documents

Ligand- and solvent-free synthesis of 2-aminobenzothiazoles by copper-catalyzed tandem reaction of 2-haloanilines with isothiocyanates

We report an environmentally friendly, efficient and practical method for the synthesis of 2-aminobenzothiazoles by a copper(II)-catalyzed tandem reaction of 2-haloanilines with isothiocyanates under ligand- and solvent-free conditions in air. The developed methodology conforms to the principles of 'green chemistry' and addresses the shortage of such methods for the synthesis of 2-aminobenzothiazoles. The reaction is quite general and generates a variety of 2-aminobenzothiazoles in good to excellent yields. Copyright

DDQ-promoted C-S bond formation: Synthesis of 2-aminobenzothiazole derivatives under transition-metal-, ligand-, and base-free conditions

A transition-metal-free method for the intramolecular S-arylation of o-halobenzothiaoureas via DDQ-mediated leading to the 2-aminobenzothiazole derivatives is reported. The reactions are performed at room temperature under ligand- and base-free conditions with good to excellent yields. Georg Thieme Verlag Stuttgart · New York.

Synthesis of 2-aminobenzothiazoles via copper(I)-catalyzed cross-coupling with part-per-million catalyst loadings

An efficient protocol has been developed for the preparation of 2-aminobenzothiazoles via a copper(I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates at very low catalyst loadings [typically 50ppm of copper(I) iodide (CuI)]. A variety of 2-iodoanilines could be cross-coupled with isothiocyanates, affording 2-aminobenzothiazoles in moderate to good yields (49-93%) under the given conditions. The turnover number (TON) of this reaction reaches 67,000 and the reaction could be scaled up, at least, to the gram-scale. Copyright