85070-58-2

Basic information

• Product Name: Methyl 2-fluoro-4-formylbenzoate
• Synonyms: Methyl 2-fluoro-4-formylbenzoate
• CAS NO: 85070-58-2
• Molecular Formula: C₉H₇FO₃
• Molecular Weight: 182.1484832
• Mol File: 85070-58-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 292.5±30.0 °C(Predicted)
• Appearance: /
• Density: 1.271±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: Methyl 2-fluoro-4-formylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 2-fluoro-4-formylbenzoate(85070-58-2)
• EPA Substance Registry System: Methyl 2-fluoro-4-formylbenzoate(85070-58-2)

Safety Data

• Hazardous Substances Data: 85070-58-2(Hazardous Substances Data)

Usage

General Description

Methyl 2-fluoro-4-formylbenzoate is a chemical compound with the molecular formula C9H7FO3. It is a derivative of benzoic acid and contains a fluoro and formyl functional group. Methyl 2-fluoro-4-formylbenzoate is commonly used as an intermediate in the synthesis of various pharmaceuticals, agrochemicals, and organic compounds. It is a clear, colorless liquid with a characteristic fruity odor and is commonly used in the laboratory for organic synthesis. Methyl 2-fluoro-4-formylbenzoate is considered to be stable under normal temperature and pressure, but should be handled with care and stored in a cool, dry place away from heat and direct sunlight.

Upstream product

• 175596-01-7 methyl 4-cyano-2-fluorobenzoate 
• 74733-29-2 2-methyl-3-hydroxybenzoic acid methyl ester 
• 7697-23-6 2-fluoro-4-methylbenzoic Acid 
• 477199-77-2 4-(bromomethyl)-2-fluorobenzoic acid 
• 141-53-7 sodium formate 
• 179232-29-2 methyl 4-bromo-2-fluorobenzoate 
• 112704-79-7 2-fluoro-4-bromobenzoic acid 
• 164149-28-4 4-cyano-2-fluorobenzoic acid 
• 1283718-57-9 methyl 2-fluoro-4-(hydroxymethyl)benzoate 
• 214554-18-4 2-fluoro-4-(hydroxymethyl)benzoic acid 

Downstream Products

• 936552-02-2 methyl 4-[1,3]dioxan-2-yl-2-fluorobenzoate 
• 161796-11-8 3-fluoro-terephthalic acid 4-methyl ester 
• 936551-93-8 methyl 4-[1,3]dioxolan-2-yl-2-fluorobenzoate 
• 1270981-54-8 methyl 4-(difluoromethyl)-2-fluorobenzoate 
• 1270977-91-7 4-{4-[4-(difluoromethyl)-2-fluorobenzoyl]piperazin-1-yl}-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]butanenitrile 
• 1190848-45-3 methyl 2-fluoro-4-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)carbonyl)benzoate 
• 1190848-49-7 methyl 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoate 
• 1190848-23-7 2-fluoro-4-(1-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)vinyl)benzoic acid 
• 1190848-41-9 methyl 4-(chlorocarbonyl)-2-fluorobenzoate 

Relevant articles and documents

NOVEL IMIDAZOLE COMPOUND AND USE THEREOF AS MELANOCORTIN RECEPTOR AGONIST

The present invention relates to a novel imidazole compound or a pharmaceutically acceptable salt thereof having a melanocortin receptor agonistic activity, and medical use thereof. The present invention relates to an imidazole compound represented by general formula [I] [wherein: Ring A represents an optionally substituted aryl group or the like; R1 represents a hydrogen atom, an optionally substituted alkyl group, or the like; R2 represents a hydrogen atom, a halogen atom, or the like; and R3 represents an optionally substituted alkyl group] or a pharmaceutically acceptable salt thereof.

AMIDE DERIVATIVES AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS

The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, formula (I) wherein R1. X, m. R2, Y, R3, Z, n, R4. A and B are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Synthesis of a new fluorine-18-labeled bexarotene analogue for PET imaging of retinoid X receptor

The reference standard 2-fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)ben-zoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and 2-fluoro-4-methylbenzoic acid in 10 steps with 3% overall chemical yield. The precursor 2-nitro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetra-hydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from 2,5-dimethyl-2,5-hexanediol and dimethyl-2-nitroterephthalate in seven steps with 2% overall chemical yield. The target tracer 2-[18F]flu-oro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid was synthesized from its nitro-precursor by the nucleophilic substitution with K[18F]F/Kryptofix 2.2.2 and isolated by HPLC combined with solid-phase extraction (SPE) purification in 20-30% radiochemical yield with 37-370 GBq/μmol specific activity at end of bombardment (EOB).