850728-18-6

Basic information

• Product Name: SN 2310
• Synonyms: SN 2310;Tenifatecan;Tocopherol succinate 7-ethyl-10-hydroxycamptothecin;d-alpha-Tocopherol succinate 7-ethyl-10-hydroxycamptothecin
• CAS NO: 850728-18-6
• Molecular Formula: C55H72N2O9
• Molecular Weight: 905.16818
• Mol File: 850728-18-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: SN 2310(CAS DataBase Reference)
• NIST Chemistry Reference: SN 2310(850728-18-6)
• EPA Substance Registry System: SN 2310(850728-18-6)

Safety Data

• Hazardous Substances Data: 850728-18-6(Hazardous Substances Data)

Usage

General Description

SN 2310 is a chemical compound primarily composed of a blend of aliphatic hydrocarbons and heavy naphtha, specifically designed for use as a solvent and diluent in various industrial applications. It is a clear, colorless liquid with a mildly sweet odor and a relatively low vapor pressure, making it suitable for use in formulations where controlled evaporation rates are required. SN 2310 is commonly used in the manufacturing of paints, coatings, adhesives, and inks, as well as in the production of industrial and consumer cleaning products. Its unique combination of properties makes it a versatile and effective ingredient for a wide range of industrial processes.

Upstream product

• 86639-52-3 7-ethyl-10-hydroxycamptothecin 
• 4345-03-3 vitamin E succinate 

Relevant articles and documents

Structure-Based Rational Design of Prodrugs to Enable Their Combination with Polymeric Nanoparticle Delivery Platforms for Enhanced Antitumor Efficacy

Drug-loaded nanoparticles (NPs) are of particular interest for efficient cancer therapy due to their improved drug delivery and therapeutic index in various types of cancer. However, the encapsulation of many chemotherapeutics into delivery NPs is often hampered by their unfavorable physicochemical properties. Here, we employed a drug reform strategy to construct a small library of SN-38 (7-ethyl-10-hydroxycamptothecin)-derived prodrugs, in which the phenolate group was modified with a variety of hydrophobic moieties. This esterification fine-tuned the polarity of the SN-38 molecule and enhanced the lipophilicity of the formed prodrugs, thereby inducing their self-assembly into biodegradable poly(ethylene glycol)-block-poly(d,l-lactic acid) (PEG-PLA) nanoparticulate structures. Our strategy combining the rational engineering of prodrugs with the pre-eminent features of conventionally used polymeric materials should open new avenues for designing more potent drug delivery systems as a therapeutic modality.

Tocopherol-modified therapeutic drug compounds

Tocopherol-modified therapeutic drug compounds; emulsion, microemulsion, and micelle formulations that include the compounds; methods for making the compounds and formulations; methods for administering the compounds and formulations; and methods for treating conditions using the compounds and formulations.